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2-Bromo-5-fluoroaniline

2-Bromo-5-fluoroaniline Structure
2-Bromo-5-fluoroaniline structure
CAS No.
1003-99-2
Chemical Name:
2-Bromo-5-fluoroaniline
Synonyms
2-Bromo-5-fluoro-phenylamine;2-Bromo-5-fluoroanil;Vandetanib Impurity 3;2-BROMO-5-FLUOROANILINE;13-Cyanophenyl&isocyanate;2-Bromo-5-fluoroaniline98%;2-Bromo-5-fluoroaniline >2-Bromo-5-fluoroaniline 98%;2-BROMO-5-FLUOROBENZENAMINE;2-Bromo-5-fluoroaniline,99%
CBNumber:
CB0184425
Molecular Formula:
C6H5BrFN
Molecular Weight:
190.01
MDL Number:
MFCD00070750
MOL File:
1003-99-2.mol
MSDS File:
SDS
Last updated:2024-11-15 19:19:13
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2-Bromo-5-fluoroaniline Properties

Melting point 43-47 °C (lit.)
Boiling point 154 °C / 23mmHg
Density 1.694±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka 1.52±0.10(Predicted)
color White to Light yellow to Dark green
InChI InChI=1S/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey FWTXFEKVHSFTDQ-UHFFFAOYSA-N
SMILES C1(N)=CC(F)=CC=C1Br
CAS DataBase Reference 1003-99-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi,T
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN2811
WGK Germany  3
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29214200
NFPA 704
1
2 0

2-Bromo-5-fluoroaniline price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 528900 2-Bromo-5-fluoroaniline 97% 1003-99-2 25g $50.4 2023-01-07 Buy
TCI Chemical B2163 2-Bromo-5-fluoroaniline >98.0%(GC) 1003-99-2 5g $56 2024-03-01 Buy
TCI Chemical B2163 2-Bromo-5-fluoroaniline >98.0%(GC) 1003-99-2 25g $166 2024-03-01 Buy
Alfa Aesar B24901 2-Bromo-5-fluoroaniline, 98% 1003-99-2 5g $51.65 2024-03-01 Buy
Alfa Aesar B24901 2-Bromo-5-fluoroaniline, 98% 1003-99-2 25g $190.65 2024-03-01 Buy
Product number Packaging Price Buy
528900 25g $50.4 Buy
B2163 5g $56 Buy
B2163 25g $166 Buy
B24901 5g $51.65 Buy
B24901 25g $190.65 Buy

2-Bromo-5-fluoroaniline Chemical Properties,Uses,Production

Description

2-bromo-5-fluoroaniline: a intermediate of antitumor drug.
2-bromo-5-fluoroaniline is the intermediate of antitumor drug Phortress, phortress is the benzothiazoles CYP1A1 antitumor drugs targeting by Univ Nottingham UK invention, solution becomes lipophilic compound 5F2O3(10 in the sensitive cells but Phortress enters), the latter is as potential aromatic hydrocarbon receptor (AhR) agonist, induce CYP1A1 to express, CYP1A1 metabolism through expressing produces and has high electrophilic active substance again, finally causes DNA damage and apoptosis. The method that, at present, synthetic 2-bromo-5-fluoronitrobenzene prepares 2-bromo-5-fluoroaniline is divided into two large classes:
The one: adopt a chemical reduction method, utilizing the chemical reducing agent reductase 2-bromo-5-fluoronitrobenzenes such as protochloride glass putty, iron powder, vat powder, hydrazine, and sodium borohydride (potassium), which is 2-bromo-5-fluoroaniline.
The 2nd: adopt hydro-reduction. What we do more often both at home and abroad at present is chloride or the catalytic hydrogenation of fluorine-containing arylamine, and the brominated less report of arylamine hydrogenation mainly is easily by hydrogenolysis because of bromine.

Chemical Properties

Yellow to brown crystalline powder

Uses

2-Bromo-5-fluoroaniline may be used to synthesize:

  • orthobromothiobenzanilide of 5-fluoronitrobenzothiazole
  • 2-bromo-5-fluorobenzo[14C]nitrile
  • [3-14C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
  • 2-bromo-5-fluoro-phenyl)-(2-methoxy-6-pentadecyl-benzyl)amine

Synthesis

A preparation method of 2-Bromo-5-fluoroaniline is as follows: methanol, 2-bromo-5-fluoronitrobenzene, W-4 type Raney nickel and bromine inhibitor are put into a hydrogenation kettle to carry out hydrogenation reaction. After the reaction is completed, the reaction solution is filtered under nitrogen protection. The filtered filtrate is then distilled under reduced pressure to remove methanol, and n-hexane is added. Then, the product is washed with process water, and after washing, the product is allowed to stand and separate. Then, the organic phase is cooled and crystallized, an off-white to brownish-yellow solid is precipitated, and a wet product is obtained by suction filtration. The wet product is dried to obtain the finished product 2-Bromo-5-fluoroaniline.

2-Bromo-5-fluoroaniline synthesis

446-09-3
1003-99-2
Synthesis of 2-Bromo-5-fluoroaniline from 1-BROMO-4-FLUORO-2-NITROBENZENE

2-Bromo-5-fluoroaniline Preparation Products And Raw materials

Raw materials

1-BROMO-4-FLUORO-2-NITROBENZENE 4-Fluoro-2-nitrobenzeneamine 3-Fluoro-4-broMoaniline 3-Fluoroaniline 4-Fluoroacetanilide
4-Fluoroaniline 4-Bromofluorobenzene

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Preparation Products

NSC-703786 8-bromo-5-fluoroquinoline Pimavanserin

2-Bromo-5-fluoroaniline Suppliers

Global( 366)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenyang TYSChem Co., Ltd.
+86-24-83607930 +8618640359690 sales@honghuchem.com China 403 58
Suzhou Nordica Biopharma CO.,LTD
+86-18136148818 +86-18567353071 3537297702@qq.com China 299 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12841 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5892 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20285 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9206 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Supplier Advantage
Shenyang TYSChem Co., Ltd.
58
Suzhou Nordica Biopharma CO.,LTD
58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Shanghai Time Chemicals CO., Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60

View Lastest Price from 2-Bromo-5-fluoroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-bromo-5-fluoroaniline pictures 2024-11-20 2-bromo-5-fluoroaniline
1003-99-2
 US $0.00-0.00 / kg 0.005kg 0.98 2 tons Suzhou Nordica Biopharma CO.,LTD
2-Bromo-5-fluoroaniline pictures 2024-10-11 2-Bromo-5-fluoroaniline
1003-99-2
 US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
2-Bromo-5-fluoroaniline pictures 2024-04-09 2-Bromo-5-fluoroaniline
1003-99-2
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

2-Bromo-5-fluoroaniline Spectrum

2-Bromo-5-fluoroaniline(1003-99-2)MS2-Bromo-5-fluoroaniline(1003-99-2)IR

1003-99-2(2-Bromo-5-fluoroaniline)Related Search:

4-Fluoroaniline 2-Fluoroaniline 4-(Trifluoromethoxy)aniline 2-Bromoaniline 2-Aminobenzotrifluoride
3-Fluoroaniline Diphenylamine Ethyl bromodifluoroacetate Bromine 2,4,5-TRIFLUORO-6-BROMOANILINE
2-AMINO-3,5-DIBROMO-6-FLUOROBENZOIC ACID 2-Bromo-4,5-difluoronitrobenzene 1-BROMO-4-FLUORO-2-NITROBENZENE 3-Fluoro-4-broMoaniline 5-BROMO-2-FLUOROANILINE
2-BROMO-6-FLUOROANILINE 3-BROMO-4-FLUOROANILINE 2-BROMO-4,5,6-TRIFLUOROANILINE

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2-BROMO-5-FLUOROBENZENAMINE 2-BROMO-5-FLUOROANILINE 2-Bromo-5-fluoroaniline 98% 2-Bromo-5-fluoroaniline98% 2-Bromo-5-fluoroaniline,99% 2-Bromo-5-fluoroanil BenzenaMine, 2-broMo-5-fluoro- 2-BroMo-5-fluoroaniline, 99% 25GR 2-broMo-5-fluoroaniline, 2-broMo-5-fluoro-phenylaMine, 2-broMo-5-fluorobenzeneaMine, 2-broMo-5-fluorobenzenaMine, 2-broMo-5-fluoro aniline, 2-broMo-5-fluoro-aniline, 2-BroM-5-fluor-anilin 2-Bromo-5-fluoroaniline ISO 9001：2015 REACH 2-Bromo-5-fluoroaniline > 2-Bromo-5-fluoro-phenylamine 13-Cyanophenyl&isocyanate Nitazoxanide Impurity 4（SU 3327） Vandetanib Impurity 3 1003-99-2 Nitrogen Compounds Organic Building Blocks C2 to C6 Amines Building Blocks Fluorinated Building Blocks Nitrogen Compounds Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Amines C2 to C6 Nitrogen Compounds Aniline Anilines, Amides & Amines Bromine Compounds Fluorine Compounds Pharmaceutical intermediate amine| alkyl bromide| alkyl Fluorine Aryl Fluorinated Building Blocks Building Blocks C6 Chemical Synthesis bc0001