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2',4',5'-TRIMETHOXYACETOPHENONE

CAS No.
1818-28-6
Chemical Name:
2',4',5'-TRIMETHOXYACETOPHENONE
Synonyms
2,4,5-TRIMETHOXYACETOPHENONE;trimethyl(1-pyrazolyl)silane;2',4',5'-Trimethoxyacetophenone;2',4',5'-TRIMETHOXYACETOPHENONE;Acetophenone, 2',4',5'-trimethoxy-;1-(2,4,5-Trimethoxyphenyl)ethanone;1-(2,4,5-trimethoxyphenyl)ethan-1-one;Ethanone, 1-(2,4,5-trimethoxyphenyl)-
CBNumber:
CB0184667
Molecular Formula:
C11H14O4
Molecular Weight:
210.23
MDL Number:
MFCD00017237
MOL File:
1818-28-6.mol
MSDS File:
SDS
Last updated:2022-12-21 16:56:50

2',4',5'-TRIMETHOXYACETOPHENONE Properties

Melting point 98-102°C
Boiling point 285-290 °C(Press: 33 Torr)
Density 1.089±0.06 g/cm3(Predicted)
FDA UNII I8G31M1PRD
EPA Substance Registry System Ethanone, 1-(2,4,5-trimethoxyphenyl)- (1818-28-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3

2',4',5'-TRIMETHOXYACETOPHENONE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 711233 2′,4′,5′-Trimethoxyacetophenone 97% 1818-28-6 25g $40.4 2024-03-01 Buy
American Custom Chemicals Corporation CHM0129205 2',4',5'-TRIMETHOXYACETOPHENONE 97.00% 1818-28-6 25G $1178.79 2021-12-16 Buy
AHH MT-31478 2,4,5-Trimethoxyacetophenone 98% 1818-28-6 10g $455 2021-12-16 Buy
Product number Packaging Price Buy
711233 25g $40.4 Buy
CHM0129205 25G $1178.79 Buy
MT-31478 10g $455 Buy

2',4',5'-TRIMETHOXYACETOPHENONE Chemical Properties,Uses,Production

Preparation

Preparation by reaction of acetyl chloride with hydroxyhydroquinone trimethyl ether in the presence of aluminium chloride.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1155, 1990 DOI: 10.1021/jm00166a012

Synthesis

2,4,5-Trimethoxy acetophenone is synthesised using 2-Hydroxy-4,5-dimethoxy acetophenone as raw material by chemical reaction. The specific synthesis steps are as follows:
2-Hydroxy-4,5-dimethoxyacetophenone(5 g,0.0255 mole) in dry acetone (100 ml)is refluxed for 30 hr under anhydrous conditions with dimethyl sulphate (2.8 ml,3.78 g,0.03 mole)and ignited potassium carbonate (20 g).The mixture is filtered and the inorganic residue washed with hot acetone (2 x 20 ml).The combined acetone solution is distilled and the oily residue macerated with crushed ice.The solid product is filtered,washed with water and dried.It is crystallised from benzene as colourless needles.Yield 4.5g (84.1%).M.p.97(lit.m.p.102).
2',4',5'-TRIMETHOXYACETOPHENONE synthesis

2',4',5'-TRIMETHOXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

2',4',5'-TRIMETHOXYACETOPHENONE Suppliers

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan Biosynce Pharmatech Co., Ltd.
+8619950309693 diane@biosynce.com China 4871 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Energy Chemical 021-021-58432009 400-005-6266 sales8178@energy-chemical.com China 44689 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 info@chemlin.com.cn China 19172 64
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
Yantai ShengKailun Chemical Technology Co., Ltd. 13356901049 3119594100@qq.com China 7958 55
Shanghai QiQiao Biological Technology Co., Ltd. 021-37653318; 15221675714 515366396@qq.com China 2089 58
Nanjing NingFan Pharm-Tech CO. LTD. 17368696818 China 1984 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 15229059051 1027@dideu.com China 9982 58
2',4',5'-TRIMETHOXYACETOPHENONE 2,4,5-TRIMETHOXYACETOPHENONE 1-(2,4,5-Trimethoxyphenyl)ethanone Acetophenone, 2',4',5'-trimethoxy- Ethanone, 1-(2,4,5-trimethoxyphenyl)- 1-(2,4,5-trimethoxyphenyl)ethan-1-one trimethyl(1-pyrazolyl)silane 2',4',5'-Trimethoxyacetophenone 1818-28-6 KETONE Aromatic Acetophenones & Derivatives (substituted)