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5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one

CAS No.
135637-46-6
Chemical Name:
5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one
Synonyms
AtizoraM;CP 80633;Atizoram, CP-80633;5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one;5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone;2(1H)-Pyrimidinone, 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-
CBNumber:
CB01855618
Molecular Formula:
C18H24N2O3
Molecular Weight:
316.39
MDL Number:
MOL File:
135637-46-6.mol
Last updated:2024-10-28 16:48:35

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Properties

Boiling point 543.0±50.0 °C(Predicted)
Density 1.178±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMF: 3 mg/ml; DMF:PBS (pH 7) (1:10): 0.1 mg/ml; DMSO: 2 mg/ml
form A crystalline solid
pka 14.05±0.40(Predicted)
FDA UNII O84FJB49WI

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13183 CP 80,633 ≥95% 135637-46-6 500μg $28 2024-03-01 Buy
Cayman Chemical 13183 CP 80,633 ≥95% 135637-46-6 1mg $50 2024-03-01 Buy
Cayman Chemical 13183 CP 80,633 ≥95% 135637-46-6 5mg $207 2024-03-01 Buy
Cayman Chemical 13183 CP 80,633 ≥95% 135637-46-6 10mg $357 2024-03-01 Buy
Tocris 2729 CP80633 ≥99%(HPLC) 135637-46-6 50 $834 2021-12-16 Buy
Product number Packaging Price Buy
13183 500μg $28 Buy
13183 1mg $50 Buy
13183 5mg $207 Buy
13183 10mg $357 Buy
2729 50 $834 Buy

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Chemical Properties,Uses,Production

Uses

CP 80633 is a selective inhibitor of phosphodiesterase type 4.

Uses

Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5’-AMP and 5’-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 μM for PDE4 versus. >100 μM for PDE1, PDE2, PDE3, and PDE5). It potentiates PGE1-dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50 < 0.6 μM), and blocks LPS-induced TNF-α release from monocytes (IC50 = 0.22 μM). CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice.[Cayman Chemical]

Definition

ChEBI: 2(1h)-pyrimidinone, 5-[3-[(1s,2s,4r)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro- is a monoterpenoid.

Biological Activity

Selective inhibitor of phosphodiesterase type 4 (IC 50 values are 1.9, > 100, > 100, > 100 and > 100 μ M for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells.? Displays anti-inflammatory and bronchodilatory effects in vivo .

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12335 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3061 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44808 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58

View Lastest Price from 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CP 80633 pictures 2024-10-28 CP 80633
135637-46-6
US $125.00 / mg 10g TargetMol Chemicals Inc.
  • CP 80633 pictures
  • CP 80633
    135637-46-6
  • US $125.00 / mg
  • TargetMol Chemicals Inc.

135637-46-6(5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one)Related Search:

5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone CP 80633 AtizoraM 2(1H)-Pyrimidinone, 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro- Atizoram, CP-80633 135637-46-6