4-Biphenylacetic acid
- CAS No.
- 5728-52-9
- Chemical Name:
- 4-Biphenylacetic acid
- Synonyms
- FELBINAC;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;2-([1,1'-biphenyl]-4-yl)acetic acid;L-141;TraxaM;LY-61017;Seltouch;CI 83544
- CBNumber:
- CB0186272
- Molecular Formula:
- C14H12O2
- Molecular Weight:
- 212.24
- MDL Number:
- MFCD00004351
- MOL File:
- 5728-52-9.mol
- MSDS File:
- SDS
Melting point | 159-160 °C (lit.) |
---|---|
Boiling point | 312.08°C (rough estimate) |
Density | 1.1035 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO: soluble50mg/mL, clear, colorless to yellow |
pka | 4.29±0.10(Predicted) |
form | Powder |
color | Beige |
Water Solubility | 39.27mg/L(25 ºC) |
Merck | 14,3316 |
BRN | 1211592 |
InChI | InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16) |
InChIKey | QRZAKQDHEVVFRX-UHFFFAOYSA-N |
SMILES | C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1 |
CAS DataBase Reference | 5728-52-9(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 94WNJ5U8L7 |
ATC code | M02AA08 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301+H331-H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P301+P310-P302+P352-P304+P340+P311-P305+P351+P338 | |||||||||
Hazard Codes | T,Xn | |||||||||
Risk Statements | 23/25-36/37/38-25-36/37/38/63-20/21/22 | |||||||||
Safety Statements | 26-36/37/39-45-37/39-28A-26/36/3745/60-20-36 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DU8229050 | |||||||||
Hazard Note | Irritant | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29163900 | |||||||||
Toxicity | LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg) | |||||||||
NFPA 704 |
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4-Biphenylacetic acid price More Price(35)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 196487 | 4-Biphenylacetic acid 98% | 5728-52-9 | 5g | $60.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 196487 | 4-Biphenylacetic acid 98% | 5728-52-9 | 25g | $120 | 2023-01-07 | Buy |
TCI Chemical | B1278 | 4-Biphenylacetic Acid >98.0%(HPLC)(T) | 5728-52-9 | 25g | $41 | 2024-03-01 | Buy |
TCI Chemical | B1278 | 4-Biphenylacetic Acid >98.0%(HPLC)(T) | 5728-52-9 | 250g | $232 | 2024-03-01 | Buy |
Alfa Aesar | A11749 | 4-Biphenylacetic acid, 98% | 5728-52-9 | 50g | $151 | 2023-06-20 | Buy |
4-Biphenylacetic acid Chemical Properties,Uses,Production
Description
Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.
Chemical Properties
Off-white powder
Originator
Lederle (USA)
Uses
Anti-inflammatory, analgesic drug.
Uses
4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.
Definition
ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.
brand name
Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).
General Description
4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.
Safety Profile
Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.
4-Biphenylacetic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Taizhou Creating Bio-pharm co., ltd. | +8613586099526 | post@creatingbiopharm.com | China | 217 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10977 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 | sales@richfortunechem.com | China | 304 | 57 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
View Lastest Price from 4-Biphenylacetic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-22 | 4-Biphenylacetic acid
5728-52-9
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-20 | 4-Biphenylacetic acid
5728-52-9
|
US $3055.00 / Kg/Drum | 25KG | 98% | 1T | Baoji Guokang Bio-Technology Co., Ltd. | |
![]() |
2024-08-17 | 4-Biphenylacetic acid
5728-52-9
|
US $3.00 / kg | 1kg | 0.99 | 10000 | Hebei Fengjia New Material Co., Ltd |
-
- 4-Biphenylacetic acid
5728-52-9
- US $0.00-0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Biphenylacetic acid
5728-52-9
- US $3055.00 / Kg/Drum
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- 4-Biphenylacetic acid
5728-52-9
- US $3.00 / kg
- 0.99
- Hebei Fengjia New Material Co., Ltd