Phenoxyacetyl chloride
- CAS No.
- 701-99-5
- Chemical Name:
- Phenoxyacetyl chloride
- Synonyms
- SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
- CBNumber:
- CB0227245
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MDL Number:
- MFCD00000726
- MOL File:
- 701-99-5.mol
- MSDS File:
- SDS
| Melting point | 100-100.5 °C |
|---|---|
| Boiling point | 225-226 °C (lit.) |
| Density | 1.235 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 227 °F |
| storage temp. | Store at RT. |
| form | Liquid |
| color | Clear slightly yellow to brown |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 607585 |
| CAS DataBase Reference | 701-99-5(CAS DataBase Reference) |
| FDA UNII | NS65CKB849 |
| NIST Chemistry Reference | Acetyl chloride, phenoxy-(701-99-5) |
| EPA Substance Registry System | Acetyl chloride, phenoxy- (701-99-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H335 | |||||||||
| Precautionary statements | P261-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 14-34-36/37 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29189090 | |||||||||
| NFPA 704 |
|
Phenoxyacetyl chloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 158623 | Phenoxyacetyl chloride 98% | 701-99-5 | 10g | $30.84 | 2024-03-01 | Buy |
| Sigma-Aldrich | 158623 | Phenoxyacetyl chloride 98% | 701-99-5 | 50g | $88.2 | 2024-03-01 | Buy |
| TCI Chemical | P0113 | Phenoxyacetyl Chloride >98.0%(GC)(T) | 701-99-5 | 25g | $30 | 2024-03-01 | Buy |
| TCI Chemical | P0113 | Phenoxyacetyl Chloride >98.0%(GC)(T) | 701-99-5 | 500g | $350 | 2024-03-01 | Buy |
| Alfa Aesar | A13761 | Phenoxyacetyl chloride, 98% | 701-99-5 | 50g | $54.65 | 2024-03-01 | Buy |
Phenoxyacetyl chloride Chemical Properties,Uses,Production
Chemical Properties
Colorless to brown liquid
Uses
Phenoxyacetyl chloride was used in the synthesis of:
- series of macrocyclic bis-β-lactams
- 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
- N-protected guanosine derivatives, useful in RNA synthesis
- phenyloxyketene, for cycloaddition to imines leading to β-lactams
Uses
Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.
Purification Methods
If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]
Phenoxyacetyl chloride Preparation Products And Raw materials
Phenoxyacetyl chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 23046 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
View Lastest Price from Phenoxyacetyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | Phenoxyacetyl chloride
701-99-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | Phenoxyacetyl Chloride
701-99-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | Phenoxyacetyl chloride
701-99-5
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- Phenoxyacetyl chloride
701-99-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Phenoxyacetyl Chloride
701-99-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Phenoxyacetyl chloride
701-99-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co