5-ETHYNYL-2'-DEOXYURIDINE
- CAS No.
- 61135-33-9
- Chemical Name:
- 5-ETHYNYL-2'-DEOXYURIDINE
- Synonyms
- abs9124;EYdU;5-E-dU;Uridine,2;Aids072372;Aids-072372;5-Ethynyl-dU;-deoxyuridine;5-Ethynyl-durd;5-Ethynyl-2'-dU
- CBNumber:
- CB0243359
- Molecular Formula:
- C11H12N2O5
- Molecular Weight:
- 252.22
- MDL Number:
- MFCD01675687
- MOL File:
- 61135-33-9.mol
- MSDS File:
- SDS
| Melting point | 199°C(lit.) |
|---|---|
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 8.29±0.10(Predicted) |
| form | powder |
| color | White or off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChIKey | CDEURGJCGCHYFH-DJLDLDEBSA-N |
| CAS DataBase Reference | 61135-33-9 |
| FDA UNII | G373S00W2J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H340-H361 |
| Precautionary statements | P201-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 46-61 |
| Safety Statements | 53-45-24/25 |
| RTECS | YU7510000 |
| HS Code | 29349990 |
5-ETHYNYL-2'-DEOXYURIDINE price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 900584 | 5-Ethynyl-2′-deoxyuridine 95% | 61135-33-9 | 50mg | $147 | 2024-03-01 | Buy |
| Sigma-Aldrich | 900584 | 5-Ethynyl-2′-deoxyuridine 95% | 61135-33-9 | 500mg | $1030 | 2024-03-01 | Buy |
| TCI Chemical | E1057 | 5-Ethynyl-2'-deoxyuridine >98.0%(HPLC)(T) | 61135-33-9 | 50mg | $89 | 2024-03-01 | Buy |
| TCI Chemical | E1057 | 5-Ethynyl-2'-deoxyuridine >98.0%(HPLC)(T) | 61135-33-9 | 200mg | $258 | 2024-03-01 | Buy |
| Cayman Chemical | 20518 | 5-Ethynyl-2'-deoxyuridine ≥98% | 61135-33-9 | 50mg | $44 | 2024-03-01 | Buy |
5-ETHYNYL-2'-DEOXYURIDINE Chemical Properties,Uses,Production
Description
5-Ethynyl-2′-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis?in vivo.1 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click ligation.1 In contrast to the use of BrdU, the new method does not require sample fixation or DNA denaturation. 5-Ethynyl-2′-deoxyuridine may be used for studying cell proliferation in the central nervous system and may be combined with BrdU staining in a novel protocol allowing for double labeling of DNA synthesis.2
Uses
5-Ethynyl-2’deoxyuridine is a extensively used nucleoside analog used as a probe for DNA synthesis. However, 5-Ethynyl-2’deoxyuridine is a toxic anti-metabolite, which potentially causes DNA instabi liy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.
Uses
5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. It has an alkyne handle that can ligate with azide-containing fluorescent probes through a highly efficient click chemistry reaction. EdU nucleoside can be incorporated into the DNA of cells either in culture or in animals without showing significant toxicity. The assay offers a simpler workflow for detecting cell proliferation than anti-BrdU assays.
For information on Baseclick kits containing all the reagents for the assays see: Baseclick kits
For a listing of the Baseclick kits see: Baseclick kits
storage
Store at -20°C
References
1) Salic and Mitchison (2008),?A chemical method for fast and sensitive detection of DNA synthesis in vivo; Proc. Natl. Acad. Sci. USA,?105?2415 2) Zeng?et al. (2010),?Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system; Brain Res.,?1319C?21
5-ETHYNYL-2'-DEOXYURIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1638 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
View Lastest Price from 5-ETHYNYL-2'-DEOXYURIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-29 | 5-Ethynyl-2'-deoxyuridine
61135-33-9
|
US $0.00-0.00 / g | 10g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | 5-Ethynyl-2'-deoxyuridine
61135-33-9
|
US $173.00-53.00 / mg | 98.1% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-02 | 5-Ethynyl-2'-deoxyuridine
61135-33-9
|
US $0.00 / g | 5g | >95.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- 5-Ethynyl-2'-deoxyuridine
61135-33-9
- US $0.00-0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-Ethynyl-2'-deoxyuridine
61135-33-9
- US $173.00-53.00 / mg
- 98.1%
- TargetMol Chemicals Inc.
-
- 5-Ethynyl-2'-deoxyuridine
61135-33-9
- US $0.00 / g
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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