(S)-1,1,1-TRIFLUORO-2-PROPANOL
- CAS No.
- 3539-97-7
- Chemical Name:
- (S)-1,1,1-TRIFLUORO-2-PROPANOL
- Synonyms
- (S)-1,1,1-Trifluoropropan-2-ol;(S)-Trifluoroisopropanol;(2S)-1,1,1-trifluoro-2-propanol;(2S)-1,1,1-Trifluoropropan-2-ol;2-Propanol, 1,1,1-trifluoro-, (2S)-;(2S)-2-Hydroxy-1,1,1-trifluoropropane;(S)-1,1,1-TRIFLUORO-2-PROPANOL (2S)-1,1,1-
- CBNumber:
- CB02448549
- Molecular Formula:
- C3H5F3O
- Molecular Weight:
- 114.07
- MDL Number:
- MFCD06797331
- MOL File:
- 3539-97-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H226-H315-H319-H335 |
| Precautionary statements | P280-P210 |
| RIDADR | UN1993 |
| HS Code | 2905599890 |
(S)-1,1,1-TRIFLUORO-2-PROPANOL price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T898550 | (S)-1,1,1-Trifluoro-2-propanol | 3539-97-7 | 50mg | $110 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2102-3-S1 | (S)-1,1,1-Trifluoropropan-2-ol 97% | 3539-97-7 | 100mg | $125 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2102-3-S1 | (S)-1,1,1-Trifluoropropan-2-ol 97% | 3539-97-7 | 250mg | $255 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2102-3-S1 | (S)-1,1,1-Trifluoropropan-2-ol 97% | 3539-97-7 | 1g | $595 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2102-3-S1 | (S)-1,1,1-Trifluoropropan-2-ol 97% | 3539-97-7 | 5G | $1495 | 2021-12-16 | Buy |
(S)-1,1,1-TRIFLUORO-2-PROPANOL Chemical Properties,Uses,Production
Description
(S)-1,1,1-Trifluoro-2-propanol is a compound important as an intermediate for various medicines and agrichemicals. Aside from methods using chemical catalysts, biological methods of reducing 1,1,1-trifluoroacetone to (S)-1,1,1-trifluoro-2-propanol by having microbial enzymes act on 1,1,1-trifluoroacetone has hitherto been studied.
Uses
(S)-1,1,1-TRIFLUORO-2-PROPANOL can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.
Uses
(S)-1,1,1-Trifluoro-2-propanol can be used as ion channel modulators to treat neurological disorders.
Synthesis
A liquid medium was prepared to be composed of 2000 ml of an ion-exchanged water, 60 g of glucose, 30 g of peptone, 50 g of yeast extract, 4.8 g of potassium dihydrogenphosphate and 2.5 g of dipotassium hydrogen phosphate. The liquid medium was charged into a fermenter of 5 L capacity (available from B.E. MARUBISHI Co., Ltd. under the trade name of a MDN-type 5L(S)) and then subjected to steam sterilization at 121°C for 60 minutes. This liquid medium was inoculated with 80 ml of a suspension of Hansenula polymorpha NBRC0799, the suspension being obtained by conducting a preliminary culture on 100 ml of the same composition to be 2.0 × 109 cfu/ml. Then, it was cultured at 28°C, an air ventilation of 1 vvm and a stirring speed of 500 rpm for 24 hours, thereby preparing a suspension of 4.3 × 109 cfu/ml (or 86 g/L in terms of the weight of wet cell bodies). At this time, adjustment of pH was attained by using aqueous ammonia, so that a pH was adjusted at 6.5. After culture had terminated, the ventilation amount and the stirring speed were changed to 0.1 vvm and 50 rpm. A solution obtained by dissolving 125.2 g of 1,1,1-trifluoroacetone and 200 g of glucose in 300 ml of an ion-exchanged water prepared in another vessel was added to the suspension automatically by a computer program in the use of an online sugar concentration sensor (an online biosensor available from ABLE & Biott Co.,Ltd. under the trade name of BF-410), so as to maintain a glucose concentration of 2 %. It was confirmed that the yield obtained after a lapse of 168 hours was 94.9 % by monitoring the reduction of the substrate due to the microorganism every 24 hours, upon which the reaction was terminated.
In order to recall 1,1,1-trifluoro-2-propanol produced from the reaction solution after termination of the reaction, distillation was performed. A distillate was recalled in an amount of 188 ml, from which it was found, by internal standard method of 19F-NMR, that 109.2 g of 1,1,1-trifluoro-2-propanol was contained. As a result of measuring the optical purity under the above-discussed analyzing conditions, the optical purity was confirmed to be 98.7% ee (S-configuration).
(S)-1,1,1-TRIFLUORO-2-PROPANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1,1,1-TRIFLUORO-2-PROPANOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17777 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30239 | 58 |
| VladaChem GmbH | +49-7246-3082843 | info@vladachem.de | Germany | 1859 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39004 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |