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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate structure

CAS No.: 1181816-12-5

Chemical Name:: tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

Synonyms: tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Boc-6-oxo-2-azaspiro[3....;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxyL;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca;ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate;tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate;tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

CBNumber:: CB02470890

Molecular Formula:: C11H17NO3

Molecular Weight:: 211.26

MDL Number:: MFCD15071430

MOL File:: 1181816-12-5.mol

MSDS File:: SDS

Last updated:2024-07-11 17:04:31

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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Properties

Melting point	114.5-116 °C
Boiling point	314.7±42.0 °C(Predicted)
Density	1.16±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	-0.93±0.20(Predicted)
form	solid
color	Pale yellow
InChI	InChI=1S/C11H17NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h4-7H2,1-3H3
InChIKey	HQHRAGXKFOTSQE-UHFFFAOYSA-N
SMILES	C1C2(CC(=O)C2)CN1C(OC(C)(C)C)=O
CAS DataBase Reference	1181816-12-5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H335-H302+H312+H332-H315
Precautionary statements	P280-P301+P312-P304+P340
HS Code	2933998090

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B809410	tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate	1181816-12-5	100mg	$60	2021-12-16	Buy
TRC	B809410	tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate	1181816-12-5	500mg	$165	2021-12-16	Buy
TRC	B809410	tert-Butyl6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate	1181816-12-5	2.5g	$605	2021-12-16	Buy
Apolloscientific	OR308105	tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate	1181816-12-5	1g	$141	2021-12-16	Buy
Matrix Scientific	070594	6-Oxo-2-azaspiro[3.3]heptane-2-carboxylicacid tert-butyl ester 95%	1181816-12-5	250mg	$457	2021-12-16	Buy

Product number	Packaging	Price	Buy
B809410	100mg	$60	Buy
B809410	500mg	$165	Buy
B809410	2.5g	$605	Buy
OR308105	1g	$141	Buy
070594	250mg	$457	Buy

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Uses,Production

Uses

tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a reagent used for the preparation of γ-butyrolactone derivative via Baeyer-Villiger monooxygenase (BVMO)-catalyzed oxidation.

Synthesis

A solution of crude tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1.00 g,4.69mmol, 1.00 equiv) in dichloromethane(20 mL) was treated with Dess-Martin periodinane(2.10g,4.95 mmol, 1.06 equiv) in two batches a few min apart at 0 °C. After 10 min, the ice bath wasremoved, and the reaction was monitored by TLC (50% ethyl acetate, PMA stain). After 30 min.the reaction was diluted with ethyl acetate and washed twice with satd sodium bicarbonate. Theorganic layer was dried over sodium sulfate, filtered, and concentrated. The crude product waspurified by flash chromatography (80g silica gel, 10 to 50% ethyl acetate/heptane; pure fractionswere identified by TLC with PMA stain; an unidentified impurity elutes slightly earlier than theproduct) to give tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate as a white solid (721 mg,73%). mp 114.5-116C.

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate synthesis

Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate from tert-butyl 5,5-dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Suppliers

Global( 187)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd	+8618068193575	sales4@btcpharm.com	China	251	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9220	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19943	58
Chengdu Feibo Pharm Technology Co., Ltd	15982321820	abby@arkpharm.com	CHINA	3274	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Chengdu Feibo Pharm Technology Co., Ltd	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-08-27	tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5	US $100.00-1600.00 / g	5g	99%	30	Zibo Hangyu Biotechnology Development Co., Ltd
2024-03-28	Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5	US $0.00 / KG	25KG	95%	Inquiry	PNP Biotech Co. Ltd
2024-02-26	Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate 1181816-12-5	US $0.00-0.00 / kg	1kg	99%	Kgs	BTC Nantong Pharmaceuticals Technology Co.,Ltd

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
US $100.00-1600.00 / g
99%
Zibo Hangyu Biotechnology Development Co., Ltd

Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
US $0.00 / KG
95%
PNP Biotech Co. Ltd

Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate
1181816-12-5
US $0.00-0.00 / kg
99%
BTC Nantong Pharmaceuticals Technology Co.,Ltd

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Spectrum

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate(1181816-12-5)¹HNMR

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6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester 6-oxo-2-azaspiro[3.3]hept... 2-Boc-6-oxo-2-azaspiro[3.... 2-Boc-6-oxo-2-azaspiro[3.3]heptane 2-Azaspiro[3.4]octane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid dimethylethyl ester tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca 6-oxo-2-azaspiro[3.3]heptane-2-carboxyL ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate 1181816-12-5 1363382-39-1 oldold MFCD22421762 oldold