Secretin | 17034-35-4

Secretin Properties

Density	1.50±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: soluble
form	powder
color	White to off-white
CAS DataBase Reference	17034-35-4
EWG's Food Scores	1
NCI Dictionary of Cancer Terms	secretin
FDA UNII	D0L9J6I13I
ATC code	V04CK01

SAFETY

Risk and Safety Statements

WGK Germany	3
F	3-10-23

Secretin price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	S0625-04A	Secretin	17034-35-4	1mg	$396	2021-12-16	Buy
Usbiological	S0625-04D	Secretin	17034-35-4	1mg	$462	2021-12-16	Buy
Usbiological	S0625-04C	Secretin	17034-35-4	1mg	$701	2021-12-16	Buy
Usbiological	S0625-04	Secretin	17034-35-4	1mg	$736	2021-12-16	Buy
Usbiological	027983	Secretin	17034-35-4	96Tests	$837	2021-12-16	Buy

Product number	Packaging	Price	Buy
S0625-04A	1mg	$396	Buy
S0625-04D	1mg	$462	Buy
S0625-04C	1mg	$701	Buy
S0625-04	1mg	$736	Buy
027983	96Tests	$837	Buy

Secretin Chemical Properties,Uses,Production

Structure

In 1970, the aa sequence of secretin was determined by Mutt to be a polypeptide comprising 27 aa residues. Secretin belongs to the secretin/glucagon superfamily, which shares significant structural and conformational homology. The family includes the vasoactive intestinal peptide (VIP), the pituitary adenylate cyclase activating peptide (PACAP), the growth hormone-releasing hormone (GHRH), peptide histidine isoleucine (PHI) or peptide histidine methionine (PHM), glucagon, glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), and the gastric inhibitory peptide (GIP). Secretin is highly conserved among mammalian species, but the sequence identity in nonmammalian species up to birds is lower than in mammals. Secretin-like sequences have not been found in teleost and lungfish genomes. Porcine secretin, Mr 3055; human secretin, 3039; chicken secretin, 3073. Soluble in water, physiological saline solution, and aqueous organic solvents. Stable in dilute hydrochloric acid at -20°C, but unstable in aqueous solution.

Gene, mRNA, and precursor

Human secretin is derived from a 121-aa residue secretin precursor consisting of a signal peptide, a short N-terminal peptide, secretin, and a C-terminal peptide. The human secretin precursor gene, SCT, location 11p15.5, consists of four exons, and the secretin coding region is exon 2. The chicken SCT gene consists of seven exons. Exons 1 and 2 are noncoding, exon 4 encodes the secretin-like peptide, and exon 5 encodes the secretin peptide.

Synthesis and release

Secretin is synthesized and secreted by S cells in the small intestine, and neurons in the brain. Secretin release is mainly stimulated by gastric acid delivered into the duodenal lumen. In addition, secretin is released by digested products of fat and protein. In canine duodenal mucosal explants, somatostatin did not alter the basal secretion of secretin but inhibited secretin secretion stimulated by pH 4.5. GABA stimulated both basal and pH 4.5-induced secretin secretion. In the brain, the estrogen-related receptor α upregulates the SCT promoter and gene expression.

Receptors

The receptor of secretin (SCTR) is a seventransmembrane GPCR that belongs to a subclass of the family B . The human SCTR consists of 440 aa residues that contain a large N-terminal extracellular domain. Cys residues and disulfide bonds in the extracellular domain have been suggested to play a key role in agonist binding. The pathway is mainly coupled to the Gs protein. Secretin activates adenylate cyclase and stimulates the production of cAMP.

Biological functions

Using northern blotting analysis, human SCTR mRNA was detected in the pancreas, intestine, colon, kidney, lung, and liver. Secretin stimulates the secretion of bicarbonate, water, and electrolytes from the ductal epithelium. In the stomach, secretin acts as an enterogastrone that inhibits gastric acid release and gastric emptying. In the kidney, secretin regulates urine output and activates adenylyl cyclase in rats. In the brain, SCTR is widely distributed in the hippocampus, central amygdala, thalamus, hypothalamus, posterior pituitary, cerebellum, and medulla oblongata. Secretin regulates social interaction, water and food intake, motor coordination, and spatial and motor learning behaviors. The zebrafish secretin receptor has been shown to be nonbioactive.

Clinical implications

The stimulatory effect of secretin on pancreatic secretion has been used in a range of clinical applications. Zollinger-Ellison syndrome is caused by a gastrin-secreting tumor (gastrinoma), and the secretin test has been used for the diagnosis of the syndrome. In the secretin test, the gastrin level is raised after intravenous secretin administration in Zollinger-Ellison syndrome patients, but not in healthy individuals. Secretin is elevated in Zollinger-Ellison patients and in patients with duodenal ulcers. Secretin levels are low in patients with pernicious anemia and achlorhydria. A clinical trial of secretin in autism has been carried out, but the clinical efficacy remains unreliable.

Description

Secretin was the first hormone identified. It is a secretagogue of pancreatic digestive juices from the porcine duodenum, used to aid in the diagnosis of gastrinoma. Secretin was discovered by Bayliss and Starling in 1902 as a secretagogue of pancreatic juices from the porcine duodenum. It was the first hormone identified.

Uses

Stimulates pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma.

brand name

SecretinKabi (KabiVitrum, Sweden).

General Description

Secretin is a 27-amino-acid polypeptide that is structurallysimilar to glucagon. The presence of acid in the small intestineis the most important physiological stimulus for the secretionof secretin. The primary action of secretin is on pancreatic acinarcells that regulate the secretion of water and bicarbonate.Secretin also promotes the secretion of pancreatic enzymes, toa lesser extent. Secretin inhibits the release of gastrin and,therefore, gastric acid. It also increases stomach-emptyingtime by reducing the contraction of the pyloric sphincter.

Clinical Use

Recombinant human secretin (SecreFlo, ChiRhoStim) is approved for use in stimulating gastrin secretion to aid in the diagnosis of gastrinoma.

Secretin Preparation Products And Raw materials

Raw materials

Preparation Products

Secretin Suppliers

Global( 177)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Chongqing Chemdad Co., Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58

View Lastest Price from Secretin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-13	Secretin Acetate 17034-35-4	US $0.00 / g	1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2024-10-25	Secretin 17034-35-4	US $40.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.
2024-08-27	Secretin 17034-35-4	US $85.00-850.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd

Secretin Acetate
17034-35-4
US $0.00 / g
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Secretin
17034-35-4
US $40.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

Secretin
17034-35-4
US $85.00-850.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

17034-35-4(Secretin)Related Search:

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Secretin Acetate SECRETIN, HUMAN Amylin (mouse, rat) CALCITONIN (8-32) (SALMON I) H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH

H-LEU-THR-ARG-PRO-ARG-TYR-OH SECRETIN (5-27) (PORCINE) SECRETIN-LYS(BIOTIN), HUMAN SECRETIN (RAT) H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

Secretin receptor DEAMINO-TYR-BETA-ALA-SECRETIN SECRETIN, HUMAN, FAM-LABELED

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Secretine Secretin-Kabi H-HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-ASP-SER-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2 H-HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-ASP-SER-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH3 HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-ASP-SER-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2 HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-ASP-SER-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2 PORCINE HSDGTFTSELSRLRDSARLQRLLQGLV-NH2 H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 hydrochloride salt Secretin (porcine) Hydrochloride Secretin actate HSDGTFTSELSRLRDSARLQRLLQGLV-NH3 SECRETIN SECRETIN ACETATE SECRETIN HEXAASPARTATE, PORCINE SECRETIN, PORCINE SECRETIN, PORCINE (1-27) secretin from porcine duodenal mucosa*partially P Secretin (pig) SECRETIN, PORCINE SYNTHETIC >97% SECRETIN FROM PORCINE DUODENAL MUCOSA PA SECRETIN PORCINE (27 AMINO ACIDS) SECRETIN HUMAN (27 AMINO ACIDS) Human Secretin Porcine secretin Secretin【ox】 Secretin Acetate, porcine Synthetic porcine secretin Secretin Acetate , pcine Secretin porcine, ≥97% (HPLC) secretin acet Secretin(trifluoroacetate salt) SECRETIN(TRIFLUOROACETATE SALT); Secretin USP/EP/BP Secretin (porcine) Hydrochloride (GMP) Rabbit Anti-Secretin antibody Aristolochic Acid Impurity 7 17034-35-4 C130H220N44O41 多肽抗原兔抗人、大、小鼠分泌素多克隆抗体 Hormones Other Protein/Peptide Hormones Peptides Secretins Cytokines, Growth Factors and Hormones Gastrointestinal Products Biochemicals and Reagents BioChemical Amino Acids and Peptides Cell Biology Cell Signaling and Neuroscience Peptide Peptides for Cell Biology Gastrointestinal Peptides SecretinPeptides for Cell Biology Hormones Other Protein/Peptide Hormones Secretins