ChemicalBook >> CAS DataBase List >>Di-tert-butyl Chloromethyl Phosphate
Di-tert-butyl Chloromethyl Phosphate
- CAS No.
- 229625-50-7
- Chemical Name:
- Di-tert-butyl Chloromethyl Phosphate
- Synonyms
- Di-tert-butyl Chloromethyl Phosphate;Phosphoric acid di-tert-butyl chloromethyl ester;Fostemsavir-SM;Foscarbidopa Impurity 20;Di-t-butyl chloromethyl phosphate;ditetrabutyl chloromethyl phosphate;Chloromethyl di-tert-butyl phosphate;Di tertiary butyl chloromethyl phosphite;Di-tert-butyl chloromethyl phosphate 95%;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
- CBNumber:
- CB02515861
- Molecular Formula:
- C9H20ClO4P
- Molecular Weight:
- 258.68
- MDL Number:
- MFCD12165895
- MOL File:
- 229625-50-7.mol
- MSDS File:
- SDS
Last updated:2024-09-26 18:30:47
| Boiling point | 272.9±23.0 °C(Predicted) |
|---|---|
| Density | 1.115±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Benzene (Slightly), Methanol (Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3 |
| InChIKey | LNJAJHJFSKUCIR-UHFFFAOYSA-N |
| SMILES | P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O |
| CAS DataBase Reference | 229625-50-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| HS Code | 29199000 |
Di-tert-butyl Chloromethyl Phosphate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D428028 | Di-tert-butylChloromethylPhosphate(stabilizedwithK2CO3) | 229625-50-7 | 50mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD137343 | Di-tert-butyl chloromethyl phosphate | 229625-50-7 | 500mg | $60 | 2021-12-16 | Buy |
| Matrix Scientific | 092558 | Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate) 95+% | 229625-50-7 | 1g | $87 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD137343 | Di-tert-butyl chloromethyl phosphate | 229625-50-7 | 1g | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD137343 | Di-tert-butyl chloromethyl phosphate | 229625-50-7 | 2g | $160 | 2021-12-16 | Buy |
Di-tert-butyl Chloromethyl Phosphate Chemical Properties,Uses,Production
Description
Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].
Uses
Used as an intermediate for laboratory research.
Synthesis
Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .
References
[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.
Synthesis of Di-tert-butyl Chloromethyl Phosphate from Chloroiodomethane and DI-TERT-BUTYLPHOSPHATE, TETRABUTYLAMMONIUM SALT
Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials
Global( 187)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Konberd Biotech Co., Ltd | +undefined18986093962 | admin@konberdbio.com | China | 1376 | 58 |
| PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD | +8618291886785 | olivia.wang@pushanshiye.com | China | 164 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
View Lastest Price from Di-tert-butyl Chloromethyl Phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-25 | Di-tert-butyl Chloromethyl Phosphate
229625-50-7
|
US $0.00-0.00 / kg | 1kg | 95+% | 100 | Wuhan Konberd Biotech Co., Ltd | |
 |
2024-10-11 | Di-Tert-Butyl Chloromethyl Phosphate
229625-50-7
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-09-26 | Di-tert-butyl Chloromethyl Phosphate
229625-50-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Di-tert-butyl Chloromethyl Phosphate
229625-50-7
- US $0.00-0.00 / kg
- 95+%
- Wuhan Konberd Biotech Co., Ltd
-
- Di-Tert-Butyl Chloromethyl Phosphate
229625-50-7
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Di-tert-butyl Chloromethyl Phosphate
229625-50-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
229625-50-7(Di-tert-butyl Chloromethyl Phosphate)Related Search:
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PHOSPHORIC ACI DI-Tert-BUTYL EXTER CHLOROMETHYL ESTER
Di-tert-butyl chloromethyl phosphate 95%
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TIANFUCHEM-- PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
Di-tert-butyl Chloromethyl Phosphate
Phosphoric acid di-tert-butyl chloromethyl ester
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Foscarbidopa Impurity 20
229625-50-7
C9H20ClO4P
intermediates
SiChem