N-Ethyl-p-menthane-3-carboxamide
- CAS No.
- 39711-79-0
- Chemical Name:
- N-Ethyl-p-menthane-3-carboxamide
- Synonyms
- WS-3;Menthol Carboxamide;ETHYL MENTHANE CARBOXAMIDE;Cooling Agent WS-3;N,2,3-trimethyl-2isopropl butanamide;FEMA 3455;Cooling taste agent ws-23;N-Ethyl-PARA-Menthan-3-Carboxamide;N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE;N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
- CBNumber:
- CB0252522
- Molecular Formula:
- C13H25NO
- Molecular Weight:
- 211.34
- MDL Number:
- MFCD00130071
- MOL File:
- 39711-79-0.mol
Melting point | 87-102 °C |
---|---|
alpha | D -49 to -54° |
Boiling point | 351.04°C (rough estimate) |
Density | 0.9305 (rough estimate) |
vapor pressure | 0.007Pa at 25℃ |
FEMA | 3455 | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE |
refractive index | 1.4410 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble) |
pka | 16.27±0.60(Predicted) |
form | powder to crystal |
color | White to Almost white |
Odor | at 25.00 % in dipropylene glycol. mild mentholic minty |
Odor Type | minty |
Water Solubility | insoluble |
Merck | 14,3825 |
JECFA Number | 1601 |
InChIKey | VUNOFAIHSALQQH-UHFFFAOYSA-N |
LogP | 2.902 at 25℃ |
CAS DataBase Reference | 39711-79-0(CAS DataBase Reference) |
Substances Added to Food (formerly EAFUS) | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE |
EWG's Food Scores | 1 |
FDA UNII | 6S7S02945H |
EPA Substance Registry System | Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H318 | |||||||||
Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P501 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36-41-22 | |||||||||
Safety Statements | 39-26 | |||||||||
WGK Germany | 2 | |||||||||
HS Code | 29242990 | |||||||||
Toxicity | LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish) | |||||||||
NFPA 704 |
|
N-Ethyl-p-menthane-3-carboxamide price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99% | 39711-79-0 | sample-k | $54.6 | 2024-03-01 | Buy |
Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG | 39711-79-0 | 100g | $144 | 2024-03-01 | Buy |
Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG | 39711-79-0 | 1kg | $690 | 2024-03-01 | Buy |
Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG | 39711-79-0 | 5kg | $1460 | 2024-03-01 | Buy |
TCI Chemical | E0796 | N-Ethyl-p-menthane-3-carboxamide >98.0%(GC) | 39711-79-0 | 5g | $19 | 2024-03-01 | Buy |
N-Ethyl-p-menthane-3-carboxamide Chemical Properties,Uses,Production
Chemical Properties
Slight menthol-like cooling effect aroma
Chemical Properties
white crystalline powder
Chemical Properties
N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.
Uses
WS 3 is a selective transient receptor potential melastatin-8 ligand.
Uses
Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.
Definition
ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.
Aroma threshold values
Aroma characteristics at 1.0%. Virtually odorless
Taste threshold values
Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.
Flammability and Explosibility
Not classified
Trade name
Winsense WS-3 (Renessenz)
Biological Activity
Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).
Synthesis
0.89
g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of
ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added
dropwise slowly while cooling in an ice bath, wherein the temperature
increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of
p-menthane-3-carbonitrile was added. The reaction solution was heated
and stirred for 102 hours at 150??C. At the end of the reaction by GC,
about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide
N-Ethyl-p-menthane-3-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 2989 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2967 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3320 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 301 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 873 | 58 |
JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 807 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Related articles
- Synthesis and Application of N-Ethyl-p-menthane-3-carboxamide
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- Oct 9,2022
View Lastest Price from N-Ethyl-p-menthane-3-carboxamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-19 | N-Ethyl-p-menthane-3-carboxamide
39711-79-0
|
US $0.00-0.00 / kg | 0.1kg | 99% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
![]() |
2024-08-19 | N-Ethyl-p-menthane-3-carboxamide;WS-3
39711-79-0
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
![]() |
2024-07-18 | N-Ethyl-p-menthane-3-carboxamide
39711-79-0
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- N-Ethyl-p-menthane-3-carboxamide
39711-79-0
- US $0.00-0.00 / kg
- 99%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- N-Ethyl-p-menthane-3-carboxamide;WS-3
39711-79-0
- US $0.00-0.00 / kg
- 99%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- N-Ethyl-p-menthane-3-carboxamide
39711-79-0
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd