ChemicalBook >> CAS DataBase List >>N-Ethyl-p-menthane-3-carboxamide
N-Ethyl-p-menthane-3-carboxamide
- CAS No.
- 39711-79-0
- Chemical Name:
- N-Ethyl-p-menthane-3-carboxamide
- Synonyms
- WS-3;Menthol Carboxamide;ETHYL MENTHANE CARBOXAMIDE;Cooling Agent WS-3;N,2,3-trimethyl-2isopropl butanamide;FEMA 3455;Cooling taste agent ws-23;N-Ethyl-PARA-Menthan-3-Carboxamide;N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE;N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
- CBNumber:
- CB0252522
- Molecular Formula:
- C13H25NO
- Molecular Weight:
- 211.34
- MDL Number:
- MFCD00130071
- MOL File:
- 39711-79-0.mol
Last updated:2024-11-19 23:02:33
| Melting point | 87-102 °C |
|---|---|
| alpha | D -49 to -54° |
| Boiling point | 351.04°C (rough estimate) |
| Density | 0.9305 (rough estimate) |
| vapor pressure | 0.007Pa at 25℃ |
| FEMA | 3455 | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE |
| refractive index | 1.4410 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble) |
| pka | 16.27±0.60(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Odor | at 25.00 % in dipropylene glycol. mild mentholic minty |
| Odor Type | minty |
| Water Solubility | insoluble |
| Merck | 14,3825 |
| JECFA Number | 1601 |
| InChIKey | VUNOFAIHSALQQH-UHFFFAOYSA-N |
| LogP | 2.902 at 25℃ |
| CAS DataBase Reference | 39711-79-0(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE |
| EWG's Food Scores | 1 |
| FDA UNII | 6S7S02945H |
| EPA Substance Registry System | Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36-41-22 | |||||||||
| Safety Statements | 39-26 | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29242990 | |||||||||
| Toxicity | LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish) | |||||||||
| NFPA 704 |
|
N-Ethyl-p-menthane-3-carboxamide price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99% | 39711-79-0 | sample-k | $54.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG | 39711-79-0 | 100g | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG | 39711-79-0 | 1kg | $690 | 2024-03-01 | Buy |
| Sigma-Aldrich | W345501 | N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide 99%, FG | 39711-79-0 | 5kg | $1460 | 2024-03-01 | Buy |
| TCI Chemical | E0796 | N-Ethyl-p-menthane-3-carboxamide >98.0%(GC) | 39711-79-0 | 5g | $19 | 2024-03-01 | Buy |
N-Ethyl-p-menthane-3-carboxamide Chemical Properties,Uses,Production
Chemical Properties
Slight menthol-like cooling effect aroma
Chemical Properties
white crystalline powder
Chemical Properties
N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.
Uses
WS 3 is a selective transient receptor potential melastatin-8 ligand.
Uses
Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.
Definition
ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.
Aroma threshold values
Aroma characteristics at 1.0%. Virtually odorless
Taste threshold values
Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.
Flammability and Explosibility
Not classified
Trade name
Winsense WS-3 (Renessenz)
Biological Activity
Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).
Synthesis
0.89
g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of
ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added
dropwise slowly while cooling in an ice bath, wherein the temperature
increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of
p-menthane-3-carbonitrile was added. The reaction solution was heated
and stirred for 102 hours at 150??C. At the end of the reaction by GC,
about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.
Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide
N-Ethyl-p-menthane-3-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 333)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3010 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2963 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567; +8618580541567 | sales@zhswyy.com | China | 303 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 874 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Related articles
- Synthesis and Application of N-Ethyl-p-menthane-3-carboxamide
- N-Ethyl-p-menthane-3-carboxamide is a refrigerant.
- Oct 9，2022
View Lastest Price from N-Ethyl-p-menthane-3-carboxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-29 | Cooling Agent Ws-3
39711-79-0
|
US $180.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-19 | TRPM8 antagonist WS-3
39711-79-0
|
US $29.00 / mL | 97.64% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | N-Ethyl-p-menthane-3-carboxamide
39711-79-0
|
US $10.00 / kg | 1kg | 99% | 100 mt | Hebei Weibang Biotechnology Co., Ltd |
-
- Cooling Agent Ws-3
39711-79-0
- US $180.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- TRPM8 antagonist WS-3
39711-79-0
- US $29.00 / mL
- 97.64%
- TargetMol Chemicals Inc.
-
- N-Ethyl-p-menthane-3-carboxamide
39711-79-0
- US $10.00 / kg
- 99%
- Hebei Weibang Biotechnology Co., Ltd
39711-79-0(N-Ethyl-p-menthane-3-carboxamide)Related Search:
N-Ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide
N-Ethyl-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide
Ethyl menthane carboxamide
Framidice 3
Menthol Carboxamide WS-3
N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXAMIDE
N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXYAMIDE
N-ETHYL 5-METHYL-2-ISO-PROPYLCYCLOHEXANECARBOXAMIDE
N-ETHYL-4-MENTHANE-3-CARBOXAMIDE
N-ETHYL-P-MENTHAN 3-CARBOXAMIDE
N-ETHYL-P-MENTHANE-3-CARBOXAMIDE
n-ethyl-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamid
MENTHANE CARBOXAMIDE
N-Ethyl-hexahydro-p-cymene-3-carboxamide
N-ETHYL-PARA-MENTHANE-3-CARBOXAMIDE
N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid
N-Ethyl-p-methane-3-carboxamide, Ethyl menthane carboxamide, Framidice 3, Menthol Carboxamide WS-3
Menthol Carboxamide WS-3
N-Ethyl-2-isopropyl-5-methylcyclohexane-1-carboxamide
N-Ethyl-p-menthane-3-carboxamide,99%
Ethyl menthane carboxamide
Framidice 3
N-Ethyl-p-menthane-3
TIMTEC-BB SBB008527
TRPM8 antagonist WS-3
CoolingSensate WS 3
N-ETHYL-PARA-MENTHAN-3-CARBOXAMIDE cooling agent
(1R,2R,5S)-N-ethyl-5-methyl-2-propan-2-yl-1-cyclohexanecarboxamide
N-Ethyl-p-menthane-3-carboxamide>
N-Ethyl-p-menthane-3-carboxamide（Cooling taste agent WS-23）
-p-menthane-3-carboxamide
N-Ethyl-p-menthane-3-carboxamide ISO 9001：2015 REACH
Cool taste WS - 3
N-ETHYL-P-MENTHAN-3-CARBOXAMIDE(WS-3)
Cooling taste agent ws-23
N,2,3-trimethyl-2isopropl butanamide
FEMA 3455
WS-3
N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
ETHYL MENTHANE CARBOXAMIDE
Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)-
N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
Menthol Carboxamide
N-Ethyl-PARA-Menthan-3-Carboxamide
Cooling Agent WS-3
N-Ethyl-2-isopropyl-5-methylcyclohexane ? ?carboxamide(WS-3)
(1R,2S,5R)-N-Ethyl-p-menthane-3-carboxamide
39711-79-0