ChemicalBook >> CAS DataBase List >>PF03716556

PF03716556

PF03716556 structure

CAS No.: 928774-43-0

Chemical Name:: PF03716556

Synonyms: CS-1022;PF 3716556;PF03716556;PF03716556 USP/EP/BP;PF-3716556 PF3716556;PF-03716556; PF03716556;PF 03716556, 10 mM in DMSO;PF3716556/PF-3716556/PF-03716556;PF-3716556;PF-03716556; PF03716556;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca

CBNumber:: CB02526164

Molecular Formula:: C22H26N4O3

Molecular Weight:: 394.47

MDL Number:: MFCD19690947

MOL File:: 928774-43-0.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

Request For Quotation

PF03716556 Properties

Melting point	143-145°C
Density	1.30
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
pka	14.18±0.10(Predicted)
color	white to tan
FDA UNII	701L6668UD
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338
WGK Germany	3

PF03716556 price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0155	PF-03716556 ≥98% (HPLC)	928774-43-0	5mg	$117	2024-03-01	Buy
Sigma-Aldrich	PZ0155	PF-03716556 ≥98% (HPLC)	928774-43-0	25mg	$545	2023-06-20	Buy
Cayman Chemical	17710	PF-3716556 ≥98%	928774-43-0	5mg	$62	2024-03-01	Buy
Cayman Chemical	17710	PF-3716556 ≥98%	928774-43-0	10mg	$109	2024-03-01	Buy
Cayman Chemical	17710	PF-3716556 ≥98%	928774-43-0	25mg	$225	2024-03-01	Buy

Product number	Packaging	Price	Buy
PZ0155	5mg	$117	Buy
PZ0155	25mg	$545	Buy
17710	5mg	$62	Buy
17710	10mg	$109	Buy
17710	25mg	$225	Buy

PF03716556 Chemical Properties,Uses,Production

Chemical Properties

Light Tan Solid

Uses

A novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

Biological Activity

the gastric h+,k+-atpase, which is responsible for gastric acid secretion, is a p2-type atpase located in the apical membrane of parietal cells. inhibition of the h+,k+-atpase is currently the most effective way to control gastric acid secretion and remains an attractive target for the medical treatment of acidrelated diseases. pf-03716556 is a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

in vitro

pf-03716556 demonstrated 3-fold greater inhibitory activity than revaprazan, the only acid pump antagonist that has been available on the market, in ion-tight assay. kinetics experiments revealed that pf-03716556 has a competitive and reversible mode of action [1].

in vivo

pf-03716556 did not display any species differences, exhibiting highly selective profile including the canine kidney h+,k+-atpase. in addition, more rapid onset of action than omeprazole and 3-fold greater potency than revaprazan were observed in ghosh-schild rats and heidenhain pouch dogs [2].

IC 50

in porcine ion-tight membrane vesicles, pf-03716556 inhibited h+,k+-atpase activity in a concentration-dependent manner, with a pic50 value of 7.095 ± 0.077 at ph 7.4.

storage

-20°C

References

[1] mori h, tonai-kachi h, ochi y, taniguchi y, ohshiro h, takahashi n, aihara t, hirao a, kato t, sakakibara m, kurebayashi y. n-(2-hydroxyethyl)-n,2-dimethyl-8-{[(4r)-5-methyl-3,4- dihydro-2h-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (pf-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. j pharmacol exp ther. 2009;328(2):671-9.

PF03716556 Preparation Products And Raw materials

Raw materials

Preparation Products

PF03716556 Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10983	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55

Supplier	Advantage
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55

View Lastest Price from PF03716556 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-20	PF 03716556 928774-43-0	US $55.00-177.00 / mg		99.68%	10g	TargetMol Chemicals Inc.

PF 03716556
928774-43-0
US $55.00-177.00 / mg
99.68%
TargetMol Chemicals Inc.

928774-43-0(PF03716556)Related Search:

G-STROPHANTHIN

8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa (R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556 [N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide] PF03716556 PF 3716556 PF-3716556;PF-03716556; PF03716556 (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca PF3716556/PF-3716556/PF-03716556 PF-03716556; PF03716556 CS-1022 Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl- PF03716556 USP/EP/BP (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide PF-3716556 PF3716556 PF 03716556, 10 mM in DMSO 928774-43-0 Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals