ChemicalBook >> CAS DataBase List >>(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)

CAS No.
940908-79-2
Chemical Name:
(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
Synonyms
R 7128;RG 7128;Mericitabine;Mericitabine/RG7128;Mericitabine,R-7128;R-7128(Mericitabine);PSI 6130 diisobutyrate;RG 7128; MERICITABINE; PSI 6130 DIISOBUTYRATE;(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate);(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
CBNumber:
CB02589653
Molecular Formula:
C18H26FN3O6
Molecular Weight:
399.41
MDL Number:
MFCD22572932
MOL File:
940908-79-2.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Properties

Boiling point 496.1±55.0 °C(Predicted)
Density 1.36
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 4.26±0.10(Predicted)
color White to off-white
FDA UNII TA63JX8X52

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0596 Mericitabine 99.47% 940908-79-2 5mg $270 2021-12-16 Buy
ApexBio Technology A3747 R-7128 940908-79-2 5mg $355 2021-12-16 Buy
ChemScene CS-0596 Mericitabine 99.47% 940908-79-2 10mg $367 2021-12-16 Buy
American Custom Chemicals Corporation API0014097 R7-128 95.00% 940908-79-2 250MG $475.65 2021-12-16 Buy
ApexBio Technology A3747 R-7128 940908-79-2 10mg $483 2021-12-16 Buy
Product number Packaging Price Buy
CS-0596 5mg $270 Buy
A3747 5mg $355 Buy
CS-0596 10mg $367 Buy
API0014097 250MG $475.65 Buy
A3747 10mg $483 Buy

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Chemical Properties,Uses,Production

Biological Activity

r-7128 is a selective nucleoside analog inhibitor of the hepatitis c virus (hcv) ns5b rna-dependent rna polymerase.hepatitis c virus (hcv) is an enveloped (+)-single stranded rna virus, and the viral rna is replicated in host cell via hcv's rna-dependent rna polymerase, which is the cause of hepatitis c and some cancer lymphomas.r-7128 is a nucleotide triphosphate analog which is the substrate for hcv polymerase ns5b. incorporation of r-7128 into nascent hcv rna strongly decreased the efficiency of rna elongation by rna polymerase ns5b, leading to the termination of the nascent rna product. it has been shown that r-7128 is able to inhibit the rna synthesis of hcv in vitro [1].32 patient infected with hcv genotype-1 was treated with r-7128 for 14 days with 750-mg or 1500-mg administered once (qd) or twice daily (bid), and the hcv rna level was frequently measured. initial decline of hcv rna was generally slower than treatment with interferon-alpha or protease inhibitors but 12 patients showed a novel pattern of hcv rna kinetics that the effectiveness in inhibiting viral production gradually increased over time to reach its final value. the final value was high with bid dose (mean 750-mg and 1500-mg: 98.0% and 99.8%, p=0.018) and significantly higher than in patients treated qd (mean qd vs bid: 90% vs 99%, p<10^-7) [2].

target

HCV

References

[1] ma h et al. , characterization of the metabolic activation of hepatitis c virus nucleoside inhibitor β-d-2′-deoxy-2′-fluoro-2′-c-methylcytidine (psi-6130) and identification of a novel active 5′-triphosphate species. j biol chem. 2007, 282(41): 29812-20.
[2] guedj j et al. , hepatitis c viral kinetics with the nucleoside polymerase inhibitor mericitabine (rg7128). hepatology. 2012, 55(4): 1030-1037.

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Preparation Products And Raw materials

Raw materials

Preparation Products

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
NewCan Biotech Limited
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Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited
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Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 sales@szzxbio.com China 2988 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61

View Lastest Price from (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mericitabine pictures 2024-11-19 Mericitabine
940908-79-2
US $45.00-153.00 / mg 98.1% 10g TargetMol Chemicals Inc.
  • Mericitabine pictures
  • Mericitabine
    940908-79-2
  • US $45.00-153.00 / mg
  • 98.1%
  • TargetMol Chemicals Inc.

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Spectrum

940908-79-2((2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate))Related Search:

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Mericitabine R 7128 RG 7128 PSI 6130 diisobutyrate Mericitabine/RG7128 R-7128(Mericitabine) Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-bis(2-methylpropanoate), (2'R)- RG 7128; MERICITABINE; PSI 6130 DIISOBUTYRATE Mericitabine,R-7128 (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) (2R,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-2-((isobutyryloxy)methyl)-4-methyltetrahydrofuran-3-yl isobutyrate 940908-79-2 C18H26FN3O6