Resorcinolnaphthalein
- CAS No.
- 41307-63-5
- Chemical Name:
- Resorcinolnaphthalein
- Synonyms
- Resorcinolnaphthalein;FTUOFHGOGJGQAB-UHFFFAOYSA-N;Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-;fibrosis,ACE2,hypertension,renal,perivascular,Resorcinolnaphthalein,reversal,inhibit,myocardial,Inhibitor,Angiotensin-converting Enzyme (ACE)
- CBNumber:
- CB02592374
- Molecular Formula:
- C24H14O5
- Molecular Weight:
- 382.36
- MDL Number:
- MOL File:
- 41307-63-5.mol
- MSDS File:
- SDS
Melting point | >290 °C |
---|---|
Boiling point | 688.4±55.0 °C(Predicted) |
Density | 1.59±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 9.13±0.20(Predicted) |
color | Light yellow to orange |
Resorcinolnaphthalein price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 5mg | $21 | 2024-03-01 | Buy |
Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 10mg | $38 | 2024-03-01 | Buy |
Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 50mg | $157 | 2024-03-01 | Buy |
Cayman Chemical | 13082 | Resorcinolnaphthalein ≥98% | 41307-63-5 | 100mg | $274 | 2024-03-01 | Buy |
ApexBio Technology | C3931 | Resorcinolnaphthalein | 41307-63-5 | 100mg | $311 | 2021-12-16 | Buy |
Resorcinolnaphthalein Chemical Properties,Uses,Production
Uses
Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is cardioprotective and renoprotective. Resorcinolnaphthalein increases the activity of ACE2 in vitro (EC50 = 19.5 μM). Activation of ACE2 in rats produces a decrease in blood pressure and improvement in cardiac function. In spontaneously hypertensive rats it produces a reversal of myocardial, perivascular, and renal fibrosis.[Cayman Chemical]
Biological Activity
resorcinolnaphthalein is an angiotensin-converting enzyme 2 (ace2) activator [1].angiotensin-converting enzyme 2 (ace2) has been involved in hydrolyzing angiotensin ii and opposing its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (pah) [2]. targeted disruption of ace2 in mice results in a severe cardiac contractility defect, increased angiotensin ii levels, and upregulation of hypoxia-induced genes in the heart [2].
in vitro
resorcinolnaphthalein enhanced ace2 activity in a dose-dependent manner [1].
in vivo
resorcinolnaphthalein caused significant activation of ace2 in both normal and diseased rats in 7 days after treatment. treatment with resorcinolnaphthalein prevented high pap, right ventricular hypertrophy and neointimal formation. resorcinolnaphthalein caused an improved endothelia-dependent vasorelaxation and decreased in proinflammatory cytokines, such as tnf-α, mcp-1, il-6, and increased in anti-inflammatory cytokine il-10 in the early stage of the pathogenesis [3]. resorcinolnaphthalein can specifically and effectively enhanced ace2 activity in rats [4]. ace2 activation by resorcinolnaphthalein showed effects on pulmonary endothelial dysfunction and neointimal formation during the development of severe pah in rats [4].
References
[1] prada j a h, ferreira a j, katovich m j, et al. structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents[j]. hypertension, 2008, 51(5): 1312-1317.
[2] crackower m a, sarao r, oudit g y, et al. angiotensin-converting enzyme 2 is an essential regulator of heart function[j]. nature, 2002, 417(6891): 822-828.
[3] haber p k, ye m, wysocki j, et al. angiotensin-converting enzyme 2–independent action of presumed angiotensin-converting enzyme 2 activatorsnovelty and significance[j]. hypertension, 2014, 63(4): 774-782.
[4] li g, liu y, zhu y, et al. ace2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats[j]. lung, 2013, 191(4): 327-336.
Resorcinolnaphthalein Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29795 | 68 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9155 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |