TriMethyl(broModifluoroMethyl)silane
- CAS No.
- 115262-01-6
- Chemical Name:
- TriMethyl(broModifluoroMethyl)silane
- Synonyms
- (BroModifluoroMethyl)triMethylsilane;(Bromodifluoromethyl);Difluorobromomethylsilane;Bromodifluoro(trimethylsilyl)methane;TriMethyl(broModifluoroMethyl)silane;Silane, (bromodifluoromethyl)trimethyl-;(Bromodifluoromethyl)trimethylsilane >Trimethyl(bromodifluoromethyl)silane 97%;(Bromodifluoromethyl)trimethylsilane 98%;(Bromodifluoromethyl)trimethylsilane, 98+%
- CBNumber:
- CB02611493
- Molecular Formula:
- C4H9BrF2Si
- Molecular Weight:
- 203.1
- MDL Number:
- MFCD18641931
- MOL File:
- 115262-01-6.mol
- MSDS File:
- SDS
Boiling point | 108°C(lit.) |
---|---|
Density | 1.306 |
refractive index | n/D1.407 |
Flash point | 46℃ |
storage temp. | -20°C |
form | liquid |
color | clear |
InChIKey | WDZVWBWAUSUTTO-UHFFFAOYSA-N |
CAS DataBase Reference | 115262-01-6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H226-H315-H319-H335 | |||||||||
Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
Risk Statements | 11 | |||||||||
Safety Statements | 24/25 | |||||||||
RIDADR | UN 1993C 3 / PGIII | |||||||||
TSCA | No | |||||||||
HazardClass | 3 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29319090 | |||||||||
NFPA 704 |
|
TriMethyl(broModifluoroMethyl)silane price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 808601 | (Bromodifluoromethyl) 98% | 115262-01-6 | 1g | $118 | 2023-01-07 | Buy |
TCI Chemical | B4325 | (Bromodifluoromethyl)trimethylsilane >98.0%(GC) | 115262-01-6 | 1g | $93 | 2024-03-01 | Buy |
TCI Chemical | B4325 | (Bromodifluoromethyl)trimethylsilane >98.0%(GC) | 115262-01-6 | 5g | $281 | 2024-03-01 | Buy |
TRC | T895825 | Trimethyl(bromodifluoromethyl)silane | 115262-01-6 | 100mg | $60 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB60402 | (Bromodifluoromethyl)trimethylsilane | 115262-01-6 | 500mg | $60 | 2021-12-16 | Buy |
TriMethyl(broModifluoroMethyl)silane Chemical Properties,Uses,Production
Chemical Properties
Colorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm3.
Uses
Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.
Uses
Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.
Uses
As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.
Application
- TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
- Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
- Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds
Reactions
(1) Difluoromethylenation of TMSCN.
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.
Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes
Ref. Angew. Chem. Int. Ed. 2022, e202115467
General Description
(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly used as a source to generate dilfluorocarbene. TMSCF3 (Ruppert–Prakash reagent) and BBr3 undergoes fast halogen–exchange reaction to form MSCF2Br.
References
[1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899
TriMethyl(broModifluoroMethyl)silane Preparation Products And Raw materials
Raw materials
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Preparation Products
TriMethyl(broModifluoroMethyl)silane Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18774 | 58 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17453 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2158 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5790 | 58 |
View Lastest Price from TriMethyl(broModifluoroMethyl)silane manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-27 | TriMethyl(broModifluoroMethyl)silane
115262-01-6
|
US $0.10 / kg | 0.004999999888241291kg | 99.99% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2022-10-10 | TriMethyl(broModifluoroMethyl)silane
115262-01-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2021-07-13 | (Bromodifluoromethyl)trimethylsilane
115262-01-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- TriMethyl(broModifluoroMethyl)silane
115262-01-6
- US $0.10 / kg
- 99.99%
- Zibo Hangyu Biotechnology Development Co., Ltd
- TriMethyl(broModifluoroMethyl)silane
115262-01-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- (Bromodifluoromethyl)trimethylsilane
115262-01-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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