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TriMethyl(broModifluoroMethyl)silane

CAS No.
115262-01-6
Chemical Name:
TriMethyl(broModifluoroMethyl)silane
Synonyms
(BroModifluoroMethyl)triMethylsilane;(Bromodifluoromethyl);Difluorobromomethylsilane;Bromodifluoro(trimethylsilyl)methane;TriMethyl(broModifluoroMethyl)silane;Silane, (bromodifluoromethyl)trimethyl-;(Bromodifluoromethyl)trimethylsilane >Trimethyl(bromodifluoromethyl)silane 97%;(Bromodifluoromethyl)trimethylsilane 98%;(Bromodifluoromethyl)trimethylsilane, 98+%
CBNumber:
CB02611493
Molecular Formula:
C4H9BrF2Si
Molecular Weight:
203.1
MDL Number:
MFCD18641931
MOL File:
115262-01-6.mol
MSDS File:
SDS
Last updated:2024-04-15 18:41:30

TriMethyl(broModifluoroMethyl)silane Properties

Boiling point 108°C(lit.)
Density 1.306
refractive index n/D1.407
Flash point 46℃
storage temp. -20°C
form liquid
color clear
InChIKey WDZVWBWAUSUTTO-UHFFFAOYSA-N
CAS DataBase Reference 115262-01-6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
Risk Statements  11
Safety Statements  24/25
RIDADR  UN 1993C 3 / PGIII
TSCA  No
HazardClass  3
PackingGroup  II
HS Code  29319090
NFPA 704
4
0 0

TriMethyl(broModifluoroMethyl)silane price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 808601 (Bromodifluoromethyl) 98% 115262-01-6 1g $118 2023-01-07 Buy
TCI Chemical B4325 (Bromodifluoromethyl)trimethylsilane >98.0%(GC) 115262-01-6 1g $93 2024-03-01 Buy
TCI Chemical B4325 (Bromodifluoromethyl)trimethylsilane >98.0%(GC) 115262-01-6 5g $281 2024-03-01 Buy
TRC T895825 Trimethyl(bromodifluoromethyl)silane 115262-01-6 100mg $60 2021-12-16 Buy
Biosynth Carbosynth FB60402 (Bromodifluoromethyl)trimethylsilane 115262-01-6 500mg $60 2021-12-16 Buy
Product number Packaging Price Buy
808601 1g $118 Buy
B4325 1g $93 Buy
B4325 5g $281 Buy
T895825 100mg $60 Buy
FB60402 500mg $60 Buy

TriMethyl(broModifluoroMethyl)silane Chemical Properties,Uses,Production

Chemical Properties

Colorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm3.

Uses

Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.

Uses

Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.

Uses

As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.

Application

  • TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
  • Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
  • Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds

Reactions

(1) Difluoromethylenation of TMSCN.
TriMethyl(broModifluoroMethyl)silane
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.
TriMethyl(broModifluoroMethyl)silane
Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes
TriMethyl(broModifluoroMethyl)silane
Ref. Angew. Chem. Int. Ed. 2022, e202115467

General Description

(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly used as a source to generate dilfluorocarbene. TMSCF3 (Ruppert–Prakash reagent) and BBr3 undergoes fast halogen–exchange reaction to form MSCF2Br.

References

[1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899

65864-64-4
115262-01-6
Synthesis of TriMethyl(broModifluoroMethyl)silane from (Difluoromethyl)trimethylsilane

TriMethyl(broModifluoroMethyl)silane Suppliers

Global( 136)Suppliers
Supplier Tel Email Country ProdList Advantage
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18774 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3009 60
Accela ChemBio Inc.
+1-858-6993322 info@accelachem.com United States 17453 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2158 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Allfluoro pharmaceutical co. ltd.
021-26137118 +8615821363818 sales@allfluoro.com China 5790 58

View Lastest Price from TriMethyl(broModifluoroMethyl)silane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TriMethyl(broModifluoroMethyl)silane pictures 2024-08-27 TriMethyl(broModifluoroMethyl)silane
115262-01-6
US $0.10 / kg 0.004999999888241291kg 99.99% 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
TriMethyl(broModifluoroMethyl)silane pictures 2022-10-10 TriMethyl(broModifluoroMethyl)silane
115262-01-6
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(Bromodifluoromethyl)trimethylsilane pictures 2021-07-13 (Bromodifluoromethyl)trimethylsilane
115262-01-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
(Bromodifluoromethyl)trimethylsilane 98% TriMethyl(broModifluoroMethyl)silane Bromodifluoro(trimethylsilyl)methane (Bromodifluoromethyl) Trimethyl(bromodifluoromethyl)silane 97% (Bromodifluoromethyl)trimethylsilane > Silane, (bromodifluoromethyl)trimethyl- Difluorobromomethylsilane TriMethyl(broModifluoroMethyl)silane ISO 9001:2015 REACH (BroModifluoroMethyl)triMethylsilane (Bromodifluoromethyl)trimethylsilane, 98+% 115262-01-6 C4H9BrF2Si