2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- CAS No.
- 112282-24-3
- Chemical Name:
- 2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- Synonyms
- BRL-52537;BRL52537;2-(3,4-DICHLOROPHENYL)-1-(2-(PYRROLIDIN-1-YLMETHYL)PIPERIDIN-1-YL)ETHANONE HCL;2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- CBNumber:
- CB02616786
- Molecular Formula:
- C18H25Cl3N2O
- Molecular Weight:
- 391.7629
- MDL Number:
- MFCD00672679
- MOL File:
- 112282-24-3.mol
- MSDS File:
- SDS
Melting point | 246-248 °C(Solv: methanol (67-56-1)) |
---|---|
storage temp. | Inert atmosphere,Room Temperature |
solubility | insoluble in H2O |
form | solid |
color | White |
Water Solubility | Soluble to 5 mM in water with gentle warming |
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B677740 | BRL52537Hydrochloride | 112282-24-3 | 100mg | $1100 | 2021-12-16 | Buy |
ApexBio Technology | B6407 | BRL52537hydrochloride | 112282-24-3 | 50mg | $843 | 2021-12-16 | Buy |
DC Chemicals | DC7891 | BRL52537HYDROCHLORIDE >98% | 112282-24-3 | 100mg | $900 | 2021-12-16 | Buy |
Alichem | 112282243 | 2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanonehydrochloride | 112282-24-3 | 1g | $943.34 | 2021-12-16 | Buy |
Ambeed | A300626 | BRL52537hydrochloride 95+% | 112282-24-3 | 5mg | $28 | 2021-12-16 | Buy |
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Chemical Properties,Uses,Production
Uses
BRL 52537 is the most selective κ/μ and one of the most potent known κ ligands. Shown to attenuate ischemia-evoked nitric oxide production. Analgesic agent.
Biological Activity
brl 52537 hydrochloride is a potent and selective agonist of κ/μ-opioid receptor with ki value of 0.24 nm for κ-opioid receptor [1].the κ-opioid receptor (kor) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. also, kor plays an important role in stress, anxiety, anhedonia, depression and increased drug-seeking behavior.brl 52537 hydrochloride is a potent and selective κ/μ-opioid receptor agonist. in the mouse tail flick model, brl 52537 showed antinociception with ed50 value of 0.05 mg/kg, which was 25 times more potent than morphine [1]. in wt male mice with middle cerebral artery occlusion, brl 52537 significantly decreased infarct volumes at 72 h of reperfusion. however, brl 52537 had no effect in neuronal no synthase null mutants (nnos-/-) mice or in the wt female mice. these results suggested that brl 52537 exhibited neuroprotection through inhibition of ischemia-evoked no production and nnos activity [2]. in adult rat dorsal root ganglia (drgs), brl 52537 inhibited tetrodotoxin-resistant (ttx-r) sodium currents in an opioid receptor-independent way, which also contributed to the antinociceptive effects [3]. in rats with cerebral ischemia/reperfusion (i/r) injury, brl52537 inhibited neuronal apoptosis and brain damage. also, brl52537 increased the level of phosphorylated stat3 and reduced caspase-3 expression [4].
storage
Store at RT
References
[1]. vecchietti v, giordani a, giardina g, et al. (2s)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. j med chem, 1991, 34(1): 397-403.
[2]. zeynalov e, nemoto m, hurn pd, et al. neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide. j cereb blood flow metab, 2006, 26(3): 414-420.
[3]. su x, castle na, antonio b, et al. the effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons. anesth analg, 2009, 109(2): 632-640.
[4]. fang s, xu h, lu j, et al. neuroprotection by the kappa-opioid receptor agonist, brl52537, is mediated via up-regulating phosphorylated signal transducer and activator of transcription-3 in cerebral ischemia/reperfusion injury in rats. neurochem res, 2013, 38(11): 2305-2312.
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
NovoChemy Ltd. | 021-31261262/ 49 (0)17662837245 | sales@novochemy.com | Germany | 6331 | 58 |
Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 41438 | 60 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3770 | 55 |
Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 9307 | 58 |
Shanghai Jizhi Biochemical Technology Co. Ltd. | 400-400-400-9004166 18616739031 | 3007523370@qq.com | China | 52712 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |