DL-4-Chlorophenylalanine
- CAS No.
- 7424-00-2
- Chemical Name:
- DL-4-Chlorophenylalanine
- Synonyms
- PCP;P-CHLOROPHENYLALANINE;Fenclonine;4-CHLORO-DL-PHENYLALANINE;2-amino-3-(4-chlorophenyl)propanoic acid;2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID;c-pal;-4-ChL;cp10,188;NSC-77370
- CBNumber:
- CB0261841
- Molecular Formula:
- C9H10ClNO2
- Molecular Weight:
- 199.63
- MDL Number:
- MFCD00002601
- MOL File:
- 7424-00-2.mol
- MSDS File:
- SDS
Melting point | >240 °C (dec.)(lit.) |
---|---|
Boiling point | 339.5±32.0 °C(Predicted) |
Density | 1.2409 (rough estimate) |
refractive index | 1.5790 (estimate) |
storage temp. | room temp |
solubility | Aqueous Acid (Slightly), Methanol (Slightly) |
form | Powder |
pka | pK1: 2.08(+1);pK2: 8.96(0) (25°C) |
color | White to almost white |
Water Solubility | slightly soluble |
BRN | 2805758 |
CAS DataBase Reference | 7424-00-2(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | R5J7E3L9SP |
EPA Substance Registry System | 4-Chlorophenylalanine (7424-00-2) |
DL-4-Chlorophenylalanine price More Price(35)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C6506 | 4-Chloro-DL-phenylalanine | 7424-00-2 | 5g | $148 | 2024-03-01 | Buy |
Sigma-Aldrich | C6506 | 4-Chloro-DL-phenylalanine | 7424-00-2 | 25g | $547 | 2024-03-01 | Buy |
TCI Chemical | C0253 | 4-Chloro-DL-phenylalanine >98.0%(T) | 7424-00-2 | 1g | $19 | 2024-03-01 | Buy |
TCI Chemical | C0253 | 4-Chloro-DL-phenylalanine >98.0%(T) | 7424-00-2 | 25g | $248 | 2024-03-01 | Buy |
Alfa Aesar | A13323 | 4-Chloro-DL-phenylalanine, 98+% | 7424-00-2 | 10g | $90.3 | 2024-03-01 | Buy |
DL-4-Chlorophenylalanine Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
- to induce insomnia in rat models
- used to treat embryos to examine its effect on serotonin
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
- to feed flies to explore serotonin effect
Uses
4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain.
Uses
An irreversible tryptophan hydroxylase inhibitor.
Definition
ChEBI: 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative.
Biological Activity
4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.
Biochem/physiol Actions
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
Safety Profile
An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and Cl-.
in vivo
4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.
storage
Room temperature
DL-4-Chlorophenylalanine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
View Lastest Price from DL-4-Chlorophenylalanine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2021-08-12 | DL-4-Chlorophenylalanine
7424-00-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
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2021-07-02 | 4-Chloro-DL-phenylalanine
7424-00-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
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2020-03-05 | DL-4-Chlorophenylalanine
7424-00-2
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- DL-4-Chlorophenylalanine
7424-00-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Chloro-DL-phenylalanine
7424-00-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- DL-4-Chlorophenylalanine
7424-00-2
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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