2-TrifluoroMethyl-2'-Methoxychalcone
- CAS No.
- 1309371-03-6
- Chemical Name:
- 2-TrifluoroMethyl-2'-Methoxychalcone
- Synonyms
- 2-TrifluoroMethyl-2'-Methoxychalcone;2-Trifluoromethyl-2'-methoxychalcone;(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;2-Propen-1-one, 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-, (2E)-
- CBNumber:
- CB02653893
- Molecular Formula:
- C17H13F3O2
- Molecular Weight:
- 306.28
- MDL Number:
- MOL File:
- 1309371-03-6.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H319-H336 | |||||||||
Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
NFPA 704 |
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2-TrifluoroMethyl-2'-Methoxychalcone price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 11881 | 2-Trifluoromethyl-2'-methoxychalcone ≥98% | 1309371-03-6 | 5mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 11881 | 2-Trifluoromethyl-2'-methoxychalcone ≥98% | 1309371-03-6 | 10mg | $107 | 2024-03-01 | Buy |
Cayman Chemical | 11881 | 2-Trifluoromethyl-2'-methoxychalcone ≥98% | 1309371-03-6 | 50mg | $437 | 2024-03-01 | Buy |
Cayman Chemical | 11881 | 2-Trifluoromethyl-2'-methoxychalcone ≥98% | 1309371-03-6 | 100mg | $765 | 2024-03-01 | Buy |
TRC | T791320 | 2-Trifluoromethyl-2''-methoxychalcone | 1309371-03-6 | 250mg | $1175 | 2021-12-16 | Buy |
2-TrifluoroMethyl-2'-Methoxychalcone Chemical Properties,Uses,Production
Uses
2-Trifluoromethyl-2''-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2''-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2''-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.
Uses
Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice. Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine compared to controls.[Cayman Chemical]
Uses
2-Trifluoromethyl-2'-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.
Biological Activity
2-trifluoromethyl-2'-methoxychalcone is a nrf2 activator.nrf2-mediated activation of antioxidant response element is a key process of molecular mechanisms regulating the protective function of phase ii detoxification and antioxidant enzymes against oxidative stress, carcinogenesis, and inflammation.
in vitro
the expression of luciferase gene under the control of nqo1-are sequence was measured using stably transfected beas-2b cells treated with 2-trifluoromethyl-2'-methoxychalcone. results showed that the exposure to 2-trifluoromethyl-2'-methoxychalcone led to a significant concentration-dependent increase in luciferase activity. moreover, beas-2b cells were coincubated with 2-trifluoromethyl-2'-methoxychalcone and with or without n-acetylcysteine, and it was found that 2-trifluoromethyl-2'-methoxychalcone could potentially increase the expression of nr2-regulated antioxidant genes in the presence of n-acetylcysteine [1].
in vivo
c57bl/6 mice were treated with a single dose of vehicle or 2-trifluoromethyl-2'-methoxychalcone or sulforaphane as the positive control, and small intestines were harvested 24 h later. results showed that the expression of gclm and nqo1 in the small intestine of mice treated with 2-trifluoromethyl-2'-methoxychalcone was 6-fold and 10-fold higher compared to vehicle, respectively. in addition, the expression of gclm and nqo1 in the small intestine treated with 2-trifluoromethyl-2'-methoxychalcone was 3-fold and 5-fold higher compared to sulforaphane, respectively [1].
References
[1] v. kumar, s. kumar, m. hassan, et al. novel chalcone derivatives as potent nrf2 activators in mice and human lung epithelial cells. journal of medicinal chemistry 54(12), 4147-4159 (2011).
2-TrifluoroMethyl-2'-Methoxychalcone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
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J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56070 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2992 | 58 |
Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 969 | 58 |
Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 15976997964; | sales-team@aobchem.com.cn | China | 50496 | 58 |