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INNO206

CAS No.
1361644-26-9
Chemical Name:
INNO206
Synonyms
Aldoxorubicin;Aldoxorubicin (INNO-206);Aldoxorubicin Aldoxorubicin;DoxorubicinImpurity16Trifluoroacetate;N-[(E)-[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide;N'-[(1E)-1-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (2E)-2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide;(E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide;(E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide;N'-((E)-1-((2S,4S)-4-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
CBNumber:
CB02666640
Molecular Formula:
C37H42N4O13
Molecular Weight:
750.75
MDL Number:
MOL File:
1361644-26-9.mol
Last updated:2024-10-28 23:16:16

INNO206 Properties

Density 1.60±0.1 g/cm3(Predicted)
storage temp. -80°, stored under nitrogen,unstable in solution, ready to use.
solubility DMSO : 75 mg/mL (99.90 mM)
form Solid
pka 7.36±0.60(Predicted)
color Purple to purplish red
FDA UNII C28MV4IM0B
NCI Drug Dictionary aldoxorubicin

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H340-H350-H360

INNO206 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1186 Aldoxorubicin 95.99% 1361644-26-9 5mg $135 2021-12-16 Buy
ChemScene CS-1186 Aldoxorubicin 95.99% 1361644-26-9 10mg $174 2021-12-16 Buy
ChemScene CS-1186 Aldoxorubicin 95.99% 1361644-26-9 50mg $695 2021-12-16 Buy
ChemScene CS-1186 Aldoxorubicin 95.99% 1361644-26-9 100mg $1180 2021-12-16 Buy
Ambeed A664813 Inno-206 98+% 1361644-26-9 100mg $1143 2021-12-16 Buy
Product number Packaging Price Buy
CS-1186 5mg $135 Buy
CS-1186 10mg $174 Buy
CS-1186 50mg $695 Buy
CS-1186 100mg $1180 Buy
A664813 100mg $1143 Buy

INNO206 Chemical Properties,Uses,Production

Biological Activity

Aldoxorubicin (INNO-206) is an albumin-bound prodrug of doxorubicin, a DNA topoisomerase II inhibitor, released from albumin under acidic conditions. It has potent antitumor activity in various cancer cell lines and mouse tumor models.

in vitro

Aldoxorubicin (INNO-206) (0.27 to 2.16 μM) inhibits blood vessel formation and reduces multiple myeloma cell growth in a pH-dependent fashion.

in vivo

Aldoxorubicin (INNO-206) (10.8 mg/kg, i.v.) shows significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor.

target

Topoisomerase II

Daunorubicins/Doxorubicins

INNO206 Preparation Products And Raw materials

Raw materials

Preparation Products

INNO206 Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
ChemExpress
+86-021-58950125 +86-021-58950125; info@chemexpress.com China 781 58
Labnetwork lnc.
+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58

View Lastest Price from INNO206 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Aldoxorubicin pictures 2024-10-28 Aldoxorubicin
1361644-26-9
US $0.00 / mg 10g TargetMol Chemicals Inc.
Aldoxorubicin Aldoxorubicin (INNO-206) N-[(E)-[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide (E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide Aldoxorubicin Aldoxorubicin 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (2E)-2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide DoxorubicinImpurity16Trifluoroacetate N'-((E)-1-((2S,4S)-4-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide (E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide N'-[(1E)-1-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 1361644-26-9