MK 5172 potassiuM salt
- CAS No.
- 1206524-86-8
- Chemical Name:
- MK 5172 potassiuM salt
- Synonyms
- MK-5172 Potassium;Grazoprevir potassium;MK5172 potassiuM salt;MK 5172 potassiuM salt;MK-5172 (potassiuM salt);Grazoprevir potassiuM salt;2)-ether potassium salt (1:1);Grazoprevir (MK-5172) potassium salt;GRAZOPREVIR POTASSIUM SALT;MK5172 POTASSIUM SALT;MK 5172 POTASSIUM SALT;(1R,2S)-N-[[[(1R,2R)-2-[5-(3-Hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcCyclopropanecarboxamide cyclic (1-2)-ether potassium salt (1:1)
- CBNumber:
- CB02666660
- Molecular Formula:
- C38H49N6O9S.K
- Molecular Weight:
- 807.02
- MDL Number:
- MFCD25976701
- MOL File:
- 1206524-86-8.mol
MK 5172 potassiuM salt price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-1375 | Grazoprevirpotassiumsalt 99.40% | 1206524-86-8 | 5mg | $108 | 2021-12-16 | Buy |
ApexBio Technology | A3620 | MK-5172potassiumsalt | 1206524-86-8 | 1mg | $126 | 2021-12-16 | Buy |
ChemScene | CS-1375 | Grazoprevirpotassiumsalt 99.40% | 1206524-86-8 | 10mg | $168 | 2021-12-16 | Buy |
ChemScene | CS-1375 | Grazoprevirpotassiumsalt 99.40% | 1206524-86-8 | 50mg | $540 | 2021-12-16 | Buy |
ChemScene | CS-1375 | Grazoprevirpotassiumsalt 99.40% | 1206524-86-8 | 100mg | $780 | 2021-12-16 | Buy |
MK 5172 potassiuM salt Chemical Properties,Uses,Production
Description
MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. IC50 Value: 7.4 nM and 7 nM for genotype 1b and 1a respectively, in replicon system [1] Target: HCV NS3/4a protease
in vitro
in vitro: In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a [2].
in vivo
in vivo: In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose [1]. Clinical trial: Evaluation of Hepatic Pharmacokinetics for MK-5172 in Participants With Chronic Hepatitis C . Phase1
References
References:[1]. Steven Harper , John A. McCauley , Michael T. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med. Chem. Lett., 2012, 3 (4), pp 332-336 [2]. Summa V, Ludmerer SW, McCauley JA, MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.
MK 5172 potassiuM salt Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
View Lastest Price from MK 5172 potassiuM salt manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | MK 5172 potassiuM salt
1206524-86-8
|
US $2.00 / kg | 1kg | 99% | ask | Career Henan Chemical Co |
- MK 5172 potassiuM salt
1206524-86-8
- US $2.00 / kg
- 99%
- Career Henan Chemical Co