ChemicalBook >> CAS DataBase List >>2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl- structure

CAS No.: 1383846-83-0

Chemical Name:: 2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-

Synonyms: AZ-4217 (AZ4217);5-[(1R)-3-amino-4-fluoro-1-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]isoindol-1-yl]-1-ethyl-3-methylpyridin-2-one;2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-

CBNumber:: CB02667546

Molecular Formula:: C30H25FN4O

Molecular Weight:: 476.54

MDL Number:: MFCD25976956

MOL File:: 1383846-83-0.mol

Last updated:2023-03-31 09:12:58

Request For Quotation

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl- Properties

Boiling point	732.5±70.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
pka	3.72±0.40(Predicted)

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl- Chemical Properties,Uses,Production

Description

AZ-4217 is a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in vivo efficacy. AZ-4217 may have potential for treatment of AD. BACE1 inhibition thus addresses a key mechanism in AD and its potential as a therapeutic target is currently being addressed in clinical studies.

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4578	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58

2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl- 5-[(1R)-3-amino-4-fluoro-1-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]isoindol-1-yl]-1-ethyl-3-methylpyridin-2-one AZ-4217 (AZ4217) 1383846-83-0