A 844606
- CAS No.
- 861119-08-6
- Chemical Name:
- A 844606
- Synonyms
- A 844606;2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one;2-(5-Methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-o ne;9H-Xanthen-9-one, 2-(hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-
- CBNumber:
- CB02696290
- Molecular Formula:
- C20H20N2O2
- Molecular Weight:
- 320.39
- MDL Number:
- MOL File:
- 861119-08-6.mol
| Melting point | >130°C (dec.) |
|---|---|
| Boiling point | 500.0±50.0 °C(Predicted) |
| Density | 1.264±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 9.91±0.20(Predicted) |
| form | Solid |
| color | Light Yellow to Yellow |
| FDA UNII | U9AMG9TJ22 |
A 844606 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4477 | A844606 ≥99%(HPLC) | 861119-08-6 | 10 | $143 | 2021-12-16 | Buy |
| Tocris | 4477 | A844606 ≥99%(HPLC) | 861119-08-6 | 50 | $576 | 2021-12-16 | Buy |
| TRC | A101230 | A844606 | 861119-08-6 | 50mg | $570 | 2021-12-16 | Buy |
| Usbiological | 254485 | A 844606 | 861119-08-6 | 10mg | $446 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004523 | A 844606 95.00% | 861119-08-6 | 5MG | $500.36 | 2021-12-16 | Buy |
A 844606 Chemical Properties,Uses,Production
Uses
A 844606 is an α7 nicotinic receptor agonists derived from tilorone.
Biological Activity
a 844606 is a potent and selective partial agonist of α7 nicotinic acetylcholine receptor (nachr) with ic50 value of 11 nm [1].the α7 nachr is a nicotinic acetylcholine receptor and is located in the brain, spleen and lymphocytes of lymph nodes. the α7 nachr plays an important role in the pathophysiology of neuropsychiatric diseases such as alzheimer’s disease, schizophrenia, drug addiction and depression [2].a 844606 is a potent and selective α7 nachr partial agonist with ic50 values of 11 and >30000 nm for α7 and α4β2, respectively. in xenopus oocytes expressed recombinant human and rat α7 nachr, a 844606 showed agonist activity with ec50 values of 1.4 and 2.2 μm, respectively. in pc12 cells, a 844606 activated α7 nachr, which stimulated erk1/2 phosphorylation [1].in the mouse brain, a 844606 showed high uptake. in monkey brain, a 844606 was mainly distributed in the thalamus and hippocampus and was low in the cerebellum. also, a 844606 was reduced by pretreatment with ssr180711, an α7 nachr agonist [2].
References
[1]. briggs ca, schrimpf mr, anderson dj, et al. alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. br j pharmacol, 2008, 153(5): 1054-1061.
[2]. toyohara j, ishiwata k, sakata m, et al. in vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11c]a-582941 and [11c]a-844606 in mice and conscious monkeys. plos one, 2010, 5(2): e8961.
A 844606 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56077 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4578 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |