LY2857785
- CAS No.
- 1619903-54-6
- Chemical Name:
- LY2857785
- Synonyms
- LY2857785;LY2857785 (LY 2857785;Cyclin dependent kinase,LY 2857785,CDK,Apoptosis,LY2857785,Inhibitor,inhibit,LY-2857785;trans-N1-(4-(3-Isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine;1,4-Cyclohexanediamine, N1-[4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-2-pyrimidinyl]-N4-(tetrahydro-2H-pyran-4-yl)-, trans-
- CBNumber:
- CB02715647
- Molecular Formula:
- C26H36N6O
- Molecular Weight:
- 448.6
- MDL Number:
- MOL File:
- 1619903-54-6.mol
| Boiling point | 671.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | insoluble in H2O; ≥13.87 mg/mL in EtOH with gentle warming; ≥2.63 mg/mL in DMSO with gentle warming and ultrasonic |
| form | Powder |
| pka | 10.05±0.40(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 | |||||||||
| NFPA 704 |
|
LY2857785 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611494 | LY2857785 | 1619903-54-6 | 5mg | $385.9 | 2021-12-16 | Buy |
| ChemScene | CS-3336 | LY2857785 98.88% | 1619903-54-6 | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-3336 | LY2857785 98.88% | 1619903-54-6 | 10mg | $600 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611494 | LY2857785 | 1619903-54-6 | 10mg | $654.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon3283 | LY2857785 98% | 1619903-54-6 | 25mg | $704 | 2021-12-16 | Buy |
LY2857785 Chemical Properties,Uses,Production
Uses
LY2857785 is a CDK9 inhibitor.
Biological Activity
ly2857785 was identified as a type i reversible and competitive atp kinase inhibitor against cdk9 and other transcription kinases cdk8 and cdk7.[1,2]cdk7 acts as a cdk-activating kinase and regulate transcription. cdk8 and cdk9 regulate transcription via phosphorylation of the rna polymerase ii carboxyl terminal domain. the cdk9-related pathway performs an important role in several biological processes, such as cell growth, proliferation, protection from apoptosis and differentiation. these kinases are reported dys-regulation in some cancers. [2]transcription activation requires phosphorylation of a carboxyl-terminal domain, by a variety of kinases including cdk7, cdk8, and cdk9. by inhibiting these kinases, ly2857785 has unique transcription inhibitor activity. ly2857785 dramatically inhibited xiap protein level in mv-4-11 and other hematologic cancer cells. it also can significantly reduce rnap ii ctd phosphorylation and dramatically decreases mcl1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. [1]ly2857785 potently inhibits a carboxyl-terminal domain phosphorylation and exhibits antitumor efficacy in orthotopic models of leukemia. ly2857785 inhibits the growth of leukemia cells, including orthotopic leukemia preclinical models as well as in ex vivo acute myeloid leukemia and chronic lymphocytic leukemia patient tumor samples. ly2857785 may be used in treating patients with hematologic tumors, particularly aml and cll. [1]
References
[1] yin t, lallena mj, kreklau el etal. , a novel cdk9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models. mol cancer ther. 2014 jun;13(6):1442-56.
[2] romano g1, giordano a. role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. cell cycle. 2008 dec;7(23):3664-8.
LY2857785 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2857785 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2990 | 60 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 309 | 55 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |
