ChemicalBook >> CAS DataBase List >>4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione structure

CAS No.: 1533519-84-4

Chemical Name:: 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

Synonyms: LES10;Lesinurad INT3;LESINURAD intermdiate;Lesinurad intermediate;4-triazole-5(4H)-thione;4-(4-Cyclopropylnaphthalen-1-yl)-1H-1;1,4-Pentanediamine,N4-(6-methoxy-11-quinolinyl)-;4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione;4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol;4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5-thione

CBNumber:: CB02725589

Molecular Formula:: C15H13N3S

Molecular Weight:: 267.35

MDL Number:: MFCD28404707

MOL File:: 1533519-84-4.mol

Last updated:2026-05-27 17:34:02

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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Properties

Boiling point	435.2±38.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	7.89±0.20(Predicted)
Appearance	White to off-white Powder
InChI	InChI=1S/C15H13N3S/c19-15-17-16-9-18(15)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-10H,5-6H2,(H,17,19)
InChIKey	UFYFJMMSOUURSF-UHFFFAOYSA-N
SMILES	N1=CN(C2=C3C(C=CC=C3)=C(C3CC3)C=C2)C(=S)N1
CAS DataBase Reference	1533519-84-4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Inactive

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	C58181	4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 97%	1533519-84-4	5g	$60	2026-05-06	Buy
Synthonix	C58181	4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 97%	1533519-84-4	1g	$80	2026-05-06	Buy
Synthonix	C58181	4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 97%	1533519-84-4	10g	$100	2026-05-06	Buy
aablocks	AA00AOEP	4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 97%	1533519-84-4	1g	$12	2026-05-28	Buy
aablocks	AA00AOEP	4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 97%	1533519-84-4	5g	$32	2026-05-28	Buy

Product number	Packaging	Price	Buy
C58181	5g	$60	Buy
C58181	1g	$80	Buy
C58181	10g	$100	Buy
AA00AOEP	1g	$12	Buy
AA00AOEP	5g	$32	Buy

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Chemical Properties, Uses, Production

Chemical Properties

Off white powder

Uses

4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is a reagent used in the discovery of Lesinurad, a HEK293 cell-based inhibitor.

Synthesis

N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide

1533519-86-6

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

1533519-84-4

Example 5. Preparation of 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiols To a round-bottomed flask was added N-(4-cyclopropyl-1-naphthalenyl)-2-formylhydrazine thiocarboxamide (64.0 g, 225 mmol), N,N-dimethylformamide (300 mL), and 1 mol/L aqueous sodium hydroxide solution (225 mL) to form a mixture. After stirring, the mixture was heated to 30 °C and kept for 16 hours. After the reaction was completed, the mixture was cooled to room temperature (about 20°C). Subsequently, 1 mol/L hydrochloric acid (about 200 mL) was slowly added to the mixture until the pH of the mixture was about 6.0, and then water (about 500 mL) was added. The mixture was stirred for 15 minutes and then filtered. The filter cake was washed with water and the product was dried under vacuum at 50 °C for 5 h to give 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol as a gray-green solid, 54.0 g in 90% yield. LC-MS: m/z (ESI): 268 (M + H)+. 1H NMR (400 MHz, acetone-d6): δ 8.57 (d, J = 8.0 Hz, 1H), 8.37 (s, 1H), 7.67 (m, 1H), 7.60 (m, 1H), 7.51 (d, J = 8.0 Hz, 1H), 7.48 (d, J = 8.0 Hz, 1H), 7.43 (d, J = 8.0 Hz, 1H), 2.50 (m, 1H), 1.16 (m, 2H), 0.84 (m, 2H).

References

[1] Patent: WO2014/198241, 2014, A1. Location in patent: Paragraph 069-070
[2] Patent: WO2014/8295, 2014, A1. Location in patent: Paragraph 0337

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione synthesis

Synthesis of 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione from N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Preparation Products And Raw materials

Raw materials

1-Cyclopropyl-4-nitronaphthalene 1-aMino-4-cyclopropylnaphthalene oxalate N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide tert-Butyl 4-cyclopropylnaphthalen-1-ylcarbamate 1-Naphthalenamine, 4-cyclopropyl-

4-Bromo-L-naphthol Naphthalene, 1-cyclopropyl-4-isothiocyanato- 1-cyclopropylnaphthalene 4-cyclopropylnaphthalen-1-aMine hydrochloride 4-Bromo-1-naphthylamine

Cyclopropylmagnesium bromide 1-Bromonaphthalene

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Preparation Products

RDEA-594 sodiuM

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Suppliers

Global Suppliers ( 189)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Feibo Chemical Technology Co., Ltd	021-58955608,2250286 15921236618	blinkzeng@gmail.com	China	522	62
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2759	65
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9417	66
Adamas Reagent, Ltd.	4006009262 13023226327	hmj@titansci.com	China	14097	59
Beijing Lunarsun Pharmaceutical Co.,LTD.	86-10-64911848-8020.8010	sales@lunarsun.com.cn	China	95	60
Jiangsu Vcare PharmaTech Co., Ltd.	025-58741518 13327700685	sales@vcarepharmatech.com	China	281	61
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	13472757003 17721485422	yongnan.wang@cendrix.cn	China	984	65
Synches Co., Ltd.	021-53292253	biz@synches.com	China	199	64
Wuhan Fortuna Chemical Co., Ltd	027-59207852 13308628970	buy@fortunachem.com	China	2664	58
Changzhou Joyous Chemical Co., Ltd.	0519-85607258	sales@joyouschem.com	China	292	60

Supplier	Advantage
Shanghai Feibo Chemical Technology Co., Ltd	62
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Beijing Lunarsun Pharmaceutical Co.,LTD.	60
Jiangsu Vcare PharmaTech Co., Ltd.	61
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	65
Synches Co., Ltd.	64
Wuhan Fortuna Chemical Co., Ltd	58
Changzhou Joyous Chemical Co., Ltd.	60

View Latest Price from 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	(4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione） 1533519-84-4	1kg	99.0%min	100kg	Hangzhou ICH Biofarm Co., Ltd
2025-12-24	4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2025-06-20	4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1533519-84-4	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.

(4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione）
1533519-84-4
99.0%min
Hangzhou ICH Biofarm Co., Ltd

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
1533519-84-4
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione
1533519-84-4
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Spectrum

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione(1533519-84-4)¹HNMR

1533519-84-4 (4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione) Related Search:

Lesinurad Impurity B Lesinurad Impurity 5 Sodium Salt Lesinurad Impurity C1 Lesinurad Impurity 2 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

Lesinurad Impurity 4 Lesinurad Impurity J Lesinurad Impurity 10 3-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 4-cyclopropylnaphthalen-1-aMine hydrochloride

Lesinurad Impurity A Methyl 2-(5-broMo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide Lesinurad Impurity N Lesinurad M4 Metabolite

Lesinurad Impurity 22 lesinurad int Naphthalene, 1-cyclopropyl-4-isothiocyanato-

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4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione lesinurad int.4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Sodium 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate 4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol 4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione (for Lesinurad) LES10 Rexinad Intermediate: 4- (1-cyclopropylnaphthalen-4-yl) -4H-1,2,4-triazole-3-thiol Lesinurad INT3 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1 4-triazole-5(4H)-thione Lesinurad intermediate LESINURAD intermdiate 4-(4-cyclopropyl naphthalene-1-yl)-4 H-1,2,4- triazole-3-thiol 4-(4-cyclopropylnaphthalene - 1-yl)-4H-1,2, 4-triazol-3-mercapta 4-(4-Cyclopropyl-1-naphthyl)-1,2,4-triazole-5(4H)-thione 4- (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5 (4H) -thioketone 4-(4-Cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thi... 1,4-Pentanediamine,N4-(6-methoxy-11-quinolinyl)- 4-(4-cyclopropyl-1-naphthyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5-thione 1533519-84-4 1533519-84-4