AC-710 Mesylate
- CAS No.
- 1351522-05-8
- Chemical Name:
- AC-710 Mesylate
- Synonyms
- AC710 Mesylate;AC 710 Mesylate;AC-710 Mesylate;AC710 Mesylate,AC-710 Mesylate
- CBNumber:
- CB02729350
- Molecular Formula:
- C32H46N6O7S
- Molecular Weight:
- 658.80864
- MDL Number:
- MFCD28138413
- MOL File:
- 1351522-05-8.mol
- MSDS File:
- SDS
AC-710 Mesylate price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Crysdot | CD31003783 | AC710Mesylate 98+% | 1351522-05-8 | 5mg | $143 | 2021-12-16 | Buy |
Crysdot | CD31003783 | AC710Mesylate 98+% | 1351522-05-8 | 10mg | $243 | 2021-12-16 | Buy |
Crysdot | CD31003783 | AC710Mesylate 98+% | 1351522-05-8 | 50mg | $917 | 2021-12-16 | Buy |
Crysdot | CD31003783 | AC710Mesylate 98+% | 1351522-05-8 | 100mg | $1459 | 2021-12-16 | Buy |
AC-710 Mesylate Chemical Properties,Uses,Production
Description
AC710 Mesylate is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively. PDGFRα|1.3 nM (Kd)|PDGFRβ|1 nM (Kd)|c-Kit|1 nM (Kd)|FLT3|0.6 nM (Kd)|CSF1R|1.57 nM (Kd)
At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stay suppressed for an extended period after dosing is halted. No body weight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. AC710 is well tolerated at the tested doses[1].
References
[1]. Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002.
AC-710 Mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
AC-710 Mesylate Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
InvivoChem | 58 |
Amadis Chemical Company Limited | 58 |
MedChemexpress LLC | 58 |
LETOPHARM LIMITED | 58 |
BOC Sciences | 65 |
Musechem | 60 |
Beijing xinyanhui pharmaceutical research and development co., LTD | 58 |
Absin Bioscience Inc. | 58 |
cjbscvictory | 58 |