5HPP-33
- CAS No.
- 105624-86-0
- Chemical Name:
- 5HPP-33
- Synonyms
- 5HPP-33;5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione;2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 2-[2,6-bis(1-methylethyl)phenyl]-5-hydroxy-
- CBNumber:
- CB02751005
- Molecular Formula:
- C20H21NO3
- Molecular Weight:
- 323.39
- MDL Number:
- MFCD03085294
- MOL File:
- 105624-86-0.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: >20mg/mL |
| form | solid |
| color | white to off-white |
| FDA UNII | 5SZ69PBV5B |
5HPP-33 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H9415 | 5HPP-33 ≥98% (HPLC), solid | 105624-86-0 | 5mg | $146 | 2024-03-01 | Buy |
| Sigma-Aldrich | H9415 | 5HPP-33 ≥98% (HPLC), solid | 105624-86-0 | 25mg | $445 | 2024-03-01 | Buy |
| TRC | H671303 | 5HPP-33 | 105624-86-0 | 10mg | $130 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0114782 | 5HPP-33 95.00% | 105624-86-0 | 5MG | $675.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0114782 | 5HPP-33 95.00% | 105624-86-0 | 25MG | $942.31 | 2021-12-16 | Buy |
5HPP-33 Chemical Properties,Uses,Production
Description
5HPP-33 is a compound that was initially identified for its anti-angiogenic properties. It suppresses microtubule dynamics and depolymerises microtubule network by binding at vinblastine site on tubulin. It is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.
Uses
5HPP-33 is a thalidomide derivative with cell-proliferation inhibitory properties.
Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).
5HPP-33 Preparation Products And Raw materials
Raw materials
Preparation Products
5HPP-33 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23980 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Energy Chemical | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |