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Oxethazaine

CAS No.
126-27-2
Chemical Name:
Oxethazaine
Synonyms
fh099;C12552;mutesa;oxaine;Wy 806;tepilta;mucaine;mucoxin;muthesa;betalgil
CBNumber:
CB0287425
Molecular Formula:
C28H41N3O3
Molecular Weight:
467.64
MDL Number:
MFCD00079202
MOL File:
126-27-2.mol
MSDS File:
SDS
Last updated:2024-12-18 13:37:16

Oxethazaine Properties

Melting point 104-105°C
Boiling point 570.1°C (rough estimate)
Density 1.0974 (rough estimate)
refractive index 1.7800 (estimate)
storage temp. Refrigerator
solubility Practically insoluble in water; freely soluble in methanol; soluble in ethyl acetate.
pka 14.62±0.10(Predicted)
form Solid
color White to Off-White
Water Solubility <0.1 g/100 mL at 23 ºC
CAS DataBase Reference 126-27-2(CAS DataBase Reference)
FDA UNII IP8QT76V17
ATC code C05AD06
EPA Substance Registry System Oxethazaine (126-27-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  AC3325000
Toxicity LD50 oral in rat: 1gm/kg

Oxethazaine price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O5380 Oxethazaine analytical standard 126-27-2 5g $160 2024-03-01 Buy
AK Scientific 2622AH Oxethazaine 126-27-2 10mg $115 2021-12-16 Buy
ApexBio Technology A8494 Oxethazaine 126-27-2 5g $150 2021-12-16 Buy
ApexBio Technology A8494 Oxethazaine 126-27-2 1g $50 2021-12-16 Buy
ApexBio Technology A8494 Oxethazaine 126-27-2 10mM(in 1mL DMSO) $50 2021-12-16 Buy
Product number Packaging Price Buy
O5380 5g $160 Buy
2622AH 10mg $115 Buy
A8494 5g $150 Buy
A8494 1g $50 Buy
A8494 10mM(in 1mL DMSO) $50 Buy

Oxethazaine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Oxaine,Wyeth,US,1960

Uses

antiviral, RT inhibitor

Uses

A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis.

Definition

ChEBI: Oxethazaine is an amino acid amide.

Manufacturing Process

Chlor-N-methyl-N-ω-phenyl-tert-butyl acetamide (23.95 g) (0.1 mol) is added to n-butanol (150.0 cc) containing anhydrous potassium carbonate (50.0 g). To the stirred refluxing solution is added dropwise freshly distilled ethanolamine (3.1 g) (0.05 mol). Stirring and refluxing is maintained for twenty hours. Upon cooling the solution is filtered; the residue is washed with n-butanol. The combined filtrates are washed with aqueous sodium carbonate solution then water and finally dried over anhydrous magnesium sulfate. The solvent is distilled under vacuum leaving a dry solid residue. The residue is dissolved in dry benzene to which is added n-hexane to crystallize the product melting at 104°C to 104.5°C. Yield 71-73%. Analysis-Carbon: calc. 71.9%; found 71.93%; hydrogen: calc. 8.8%; found 8.9%; nitrogen: calc. 9.0%; found 9.0%.
To make the hydrochloride salt, the bisacetamide or, by another name, 1,11diphenyl-2,2,3,9,10,10-hexamethyl-4,8-diketo-6-(β-hydroxyethyl)-3,6,9triazaundecane is dissolved in n-butanol. The solution is chilled and then dry hydrogen chloride gas is passed into the solution causing an oil to separate. To the heavy oil ether is added and then stirred causing crystallization to occur. MP 146°C to 147°C. Analysis for nitrogen: calc. 83%. found 8.2%.
To make the acetate salt, the bisacetamide (4.7 g) (0.01 mol) is dissolved in ethyl acetate to which is added glacial acetic acid (0.6 g) (0.01 mol). Ether is added to precipitate the acetate as a gum which is washed with hexane, and finally added to dry ether. Allow to stand for crystallization. MP 141°C. Analysis for nitrogen: calc. 8.0%; found 8.2%.
Other salts are: sulfate, MP 56°C; acid oxalate, MP 127°C; tartrate, MP 45°C; picrate, MP 151°C to 152°C.

Therapeutic Function

Local anesthetic

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A hydroxylated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data are not available for Oxethazaine, but Oxethazaine is probably combustible.

Oxethazaine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15352 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 49978 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33338 58

View Lastest Price from Oxethazaine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Oxethazaine pictures 2024-11-19 Oxethazaine
126-27-2
US $30.00-56.00 / mg 100% 10g TargetMol Chemicals Inc.
Oxethazaine pictures 2024-11-19 Oxethazaine
126-27-2
US $30.00-56.00 / mg 100% 10g TargetMol Chemicals Inc.
Oxethazaine pictures 2021-08-12 Oxethazaine
126-27-2
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Oxethazaine pictures
  • Oxethazaine
    126-27-2
  • US $30.00-56.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
  • Oxethazaine pictures
  • Oxethazaine
    126-27-2
  • US $30.00-56.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
  • Oxethazaine pictures
  • Oxethazaine
    126-27-2
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
OXETHAZAINE OXETHAZINE OXETACAINE 2-hydroxyethyliminobis(n-[α,α-dimethylphenethyl]-n-methylacetamide) 2,2'-[(2-Hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methylacetamide] Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl- C12552 2,2’-((2-hydroxyethyl)imino)bis(n-(1,1-dimethyl-2-phenylethyl)-n-methylaceta 2,2’-((2-hydroxyethyl)imino)bis(n-(alpha,alpha-dimethylphenethyl)-n-acetamid 2,2’-((2-hydroxyethyl)imino)bis(n-(alpha,alpha-dimethylphenethyl)-n-methylac acetamide,2,2’-(2-hydroxyethyl)imino)bis(n-(1,1-dimethylphenylethyl)-n-methy betalgil fh099 oxethacaine stomacain tepilta topicain 2-HYDROXYETHYLIMINOBIS-[N-(ALPHA,ALPHA-DIMETHYLPHENETHYL)-N-METHYLACETAMIDE] 2-di(n-methyl-n-phenyl-tert-butyl-carbamoylmethyl)aminoethanol N,N-bis(alpha,alpha-dimethylphenethyl)-N,N-dimethyl-2,2-(2-hydroxyethylimino)di(acetamide) mucaine mucoxin mutesa muthesa n,n-bis(n-methyl-n-phenyl-tert-butylacetamido)-beta-hydroxyethylamine oxaine oxethacaina 2,2'-[(2-Hydroxyethyl)iMino]bis[N-(α,α-diMethylphenethyl)-N-MethylacetaMide] Storocain Storocaine Wy 806 Oxethazaine API - BP OxetacaineQ: What is Oxetacaine Q: What is the CAS Number of Oxetacaine Q: What is the storage condition of Oxetacaine Q: What are the applications of Oxetacaine peptic ulcer disease,hemorrhoid,Inhibitor,esophagitis,HBV,analgesic,Oxethazaine,inhibit,precursor,Hepatitis B virus Clopamide Impurity 2 (Clopamide EP Impurity B) 126-27-2 C28H41N3O3 Analytical Standards Analytical Chromatography Product Catalog Alphabetic VIRAMUNE Aromatics Intermediates & Fine Chemicals Pharmaceuticals Amines