Lysine N-methyltransferase 1C
- CAS No.
- Chemical Name:
- Lysine N-methyltransferase 1C
- Synonyms
- G9a;Bat8;EHMT2;KMT1C;G9a human;D17Ertd710e;Lysine N-methyltransferase 1C;HLA-B-associated transcript 8;Euchromatic histone-lysine N-methyltransferase 2
- CBNumber:
- CB02915160
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Lysine N-methyltransferase 1C price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP0136 | G9a human recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE) | 20μg | $687 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SRP0135 | G9a human recombinant, expressed in E. coli, ≥70% (SDS-PAGE) | 50μg | $689 | 2024-03-01 | Buy | |
| Biorbyt Ltd | orb528858 | EHMT2 | 10μg | $1939.7 | 2021-12-16 | Buy |
Lysine N-methyltransferase 1C Chemical Properties,Uses,Production
Uses
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
General Description
Human G9a (euchromatic histone-lysine N-methyltransferase 2) with N-terminal GST tag, MW = 74.6 kDa, expressed in an E. coli expression system. G9a is a member of SET (Su(var)3-9, enhancer-of-zeste and trithorax) domain containing, Su(var)3-9 family of proteins. This domain is evolutionary conserved.
Biochem/physiol Actions
The encoded protein G9a (euchromatic histone-lysine N-methyltransferase 2) is a methyltransferase that methylates lysine residues of histone H3. Overexpression of G9a is observed in cancer. It is known to participate in cancer cell migration, invasion and metastasis. G9a is an epigenetic regulator and can inhibit the action of tumor suppressor genes, thereby, contributes to carcinogenesis. Thus, G9a is considered to be an oncogenic and metastatic factor. It also affects DNA damage repair mechanism, which might make tumor cells resistant to radiation and chemotherapy. G9a serves as a target for cancer therapy including breast cancer.
Lysine N-methyltransferase 1C Preparation Products And Raw materials
Raw materials
Preparation Products
Lysine N-methyltransferase 1C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 13774214275 | zhouzz@univ-bio.com | China | 25002 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 292394 | 58 |
| Beijing Biosynthesis Biotechnology Co Ltd | 400-9019800 | sales@bioss.com.cn | China | 38102 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
| Merck KGaA | 58 |
| Beijing Biosynthesis Biotechnology Co Ltd | 58 |