Biological Activity
CAMKV (CaM kinase-like vesicle-associated) gene encodes a member of the CaMK (Ca2+/calmodulin-dependent protein kinases) superfamily th at mediate stimulus–secretion coupling and excitation–contraction coupling in various cell types. The protein is a monomer of 41kDa th at is 504 amino acids long and is found to be associated with perikaryal membranes and neurites. This calmodulin binding protein is also associated with vesicles in both axons and dendrites. It is found to be associated with membranes and vesicles present in neurites of subsets of noncerebellar neurons. The N-terminal domain of this protein exhibits high similarity to the catalytic and calmodulin-binding domains of CaMKII, another member of the same family. The C-terminus contains an eight-residue motif DR/GSA/VTP at th at may be related to PEST sequences th at confer half-life to proteins in which they are present. It contains a 19-residue hydrophobic region th at may span a membrane and a 32-residue uncharged region. This protein resembles other members of the family and may function as a calmodulin-binding protein kinase.
