ChemicalBook >> CAS DataBase List >>BC2059
BC2059
- CAS No.
- 1227637-23-1
- Chemical Name:
- BC2059
- Synonyms
- BC2059;Tegavivint;Tegoprazan D6;Tegatrabetan (BC2059);BC-2059;BC2059;TEGAVIVINT;TEGATRABETAN;BC-2059;TEGAVIVINT;Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059;rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime;9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-
- CBNumber:
- CB03038499
- Molecular Formula:
- C28H36N4O6S2
- Molecular Weight:
- 588.74
- MDL Number:
- MOL File:
- 1227637-23-1.mol
Last updated:2024-07-02 08:54:57
Boiling point | 757.6±70.0 °C(Predicted) |
---|---|
Density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO: 125 mg/mL (212.32 mM) |
pka | 10.07±0.20(Predicted) |
form | Solid |
color | White to light yellow |
FDA UNII | 18AP231HUP |
NCI Drug Dictionary | tegavivint |
BC2059 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0039507 | Tegatrabetan 98.19% | 1227637-23-1 | 5mg | $90 | 2021-12-16 | Buy |
ChemScene | CS-0039507 | Tegatrabetan 98.19% | 1227637-23-1 | 10mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0039507 | Tegatrabetan 98.19% | 1227637-23-1 | 50mg | $430 | 2021-12-16 | Buy |
DC Chemicals | DC20756 | Tegatrabetan >98% | 1227637-23-1 | 100mg | $650 | 2021-12-16 | Buy |
DC Chemicals | DC20756 | Tegatrabetan >98% | 1227637-23-1 | 1g | $2500 | 2021-12-16 | Buy |
BC2059 Chemical Properties,Uses,Production
Biological Activity
Tegatrabetan (BC2059) is a beta-Catenin antagonist. It disrupts β-catenin binding to scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and reduces β-catenin nuclear levels.
in vivo
Tegatrabetan (BC2059; 1.0 or 5.0 mg/kg/day; intravenously) significantly improves the median survival of the mice from approximately 17.5 to 39 days. Treatment with Tegatrabetan (10 mg/kg/day; intravenously) alone further improves the median survival to 51.5 days.
Animal Model: | NOD/SCID mice bearing OCI-AML3 xenografts | < /tr>
Dosage: | 1 mg/kg; 5 mg/kg; 10 mg/kg |
Administration: | Intravenously; 1 mg/kg daily 4 days per week or 5 mg/kg or 10 mg/kg of BC2059 twice per week (Tuesday and Thursday) for 3 weeks. |
Result: | Treatment significantly improved survival of NOD/SCID mice bearing OCI-AML3 xenografts. |
target
Target | Value |
β-catenin () |
BC2059 Preparation Products And Raw materials
Raw materials
Preparation Products
BC2059 Suppliers
Global( 28)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4197 | 55 |
BC2059
BC-2059;BC2059;TEGAVIVINT
Tegavivint
TEGATRABETAN;BC-2059;TEGAVIVINT
9,10-Anthracenedione, 2,7-bis[[(3R,5S)-3,5-dimethyl-1-piperidinyl]sulfonyl]-, 9,10-dioxime, rel-
rel-2,7-Bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime
Tegatrabetan (BC2059)
Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059
Tegoprazan D6
1227637-23-1