t-Boc-N-amido-PEG1-acid
- CAS No.
- 1260092-44-1
- Chemical Name:
- t-Boc-N-amido-PEG1-acid
- Synonyms
- 3-(2-((tert-Butoxycarbonyl)amino)ethoxy)propanoic acid;Boc-NH-PEG1-COOH;NH-PEG1-CH2CH2COOH;Boc-PEG1-CH2CH2COOH;Boc-N-amido-PEG1-acid;Boc-NH-PEG1-CH2CH2COOH;t-Boc-N-amido-PEG1-acid;t-Boc-N-amido-PEG1-CH2COOH;t-Boc-N-amido-PEG1-acid t-Boc;t-boc-N-amido-PEG1-propionic acid
- CBNumber:
- CB03062663
- Molecular Formula:
- C10H19NO5
- Molecular Weight:
- 233.26
- MDL Number:
- MFCD22574796
- MOL File:
- 1260092-44-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
t-Boc-N-amido-PEG1-acid price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B671343 | Boc-NH-PEG1-CH2CH2COOH | 1260092-44-1 | 10mg | $45 | 2021-12-16 | Buy |
| BroadPharm | BP-20910 | t-Boc-N-amido-PEG1-acid 98% | 1260092-44-1 | 1g | $200 | 2021-12-16 | Buy |
| Apolloscientific | BIPG1799 | t-Boc-N-amido-PEG1-acid | 1260092-44-1 | 500mg | $410 | 2021-12-16 | Buy |
| AK Scientific | 0262DB | 3-(2-((Tert-butoxycarbonyl)amino)ethoxy)propanoicacid | 1260092-44-1 | 5g | $531 | 2021-12-16 | Buy |
| BroadPharm | BP-20910 | t-Boc-N-amido-PEG1-acid 98% | 1260092-44-1 | 5G | $625 | 2021-12-16 | Buy |
t-Boc-N-amido-PEG1-acid Chemical Properties,Uses,Production
Description
t-Boc-N-amido-PEG1-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].
Biological Activity
Boc-NH-PEG1-CH2CH2COOH is a cleavable ADC linker containing 1 unit PEG, and also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used for the synthesis of antibody-drug conjugates (ADC) and PROTACs .
target
| PEGs
| Alkyl/ether
| Cleavable
|
IC 50
PEGs; Alkyl/ether; Cleavable Linker
References
[1] Alex Cortez, et al.Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.
[2] Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.
t-Boc-N-amido-PEG1-acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19825 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32219 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
View Lastest Price from t-Boc-N-amido-PEG1-acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-21 | t-Boc-N-amido-PEG1-acid
1260092-44-1
|
US $0.00-0.00 / g | 1g | 98 | 1000 | Wuhan Circle Star Chem-medical Technology Co.,Ltd | |
 |
2024-10-24 | Boc-NH-PEG1-CH2CH2COOH
1260092-44-1
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-03-25 | t-Boc-N-amido-PEG1-acid
1260092-44-1
|
US $0.00 / g | 25g | >98.00% | 25g | Xian confluore Biological Technology Co., Ltd. |
-
- t-Boc-N-amido-PEG1-acid
1260092-44-1
- US $0.00-0.00 / g
- 98
- Wuhan Circle Star Chem-medical Technology Co.,Ltd
-
- Boc-NH-PEG1-CH2CH2COOH
1260092-44-1
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- t-Boc-N-amido-PEG1-acid
1260092-44-1
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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