CC-115 (hydrochloride)
- CAS No.
- 1300118-55-1
- Chemical Name:
- CC-115 (hydrochloride)
- Synonyms
- CC-115 HCl;CC-115 (hydrochloride)
- CBNumber:
- CB03067002
- Molecular Formula:
- C16H17ClN8O
- Molecular Weight:
- 372.82
- MDL Number:
- MOL File:
- 1300118-55-1.mol
CC-115 (hydrochloride) price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-5379 | CC-115(hydrochloride) 97.22% | 1300118-55-1 | 5mg | $90 | 2021-12-16 | Buy |
ChemScene | CS-5379 | CC-115(hydrochloride) 97.22% | 1300118-55-1 | 10mg | $150 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611858 | CC-115 hydrochloride >98% | 1300118-55-1 | 10mg | $402.9 | 2021-12-16 | Buy |
ChemScene | CS-5379 | CC-115(hydrochloride) 97.22% | 1300118-55-1 | 50mg | $520 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611858 | CC-115 hydrochloride >98% | 1300118-55-1 | 50mg | $793.9 | 2021-12-16 | Buy |
CC-115 (hydrochloride) Chemical Properties,Uses,Production
Description
CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
CC-115 inhibits PC-3 cells proliferation with an IC50 of 138 nM. In a kinase selectivity assessment against a panel of 250 protein kinases at 3 μM, only one kinase other than mTOR kinase is identified with more than 50% inhibition (cFMS 57%, IC50=2.0 μM). Of the PI3K related kinases (PIKKs) tested, CC-115 proves to be equipotent against DNA PK (IC50=15 nM) and demonstrates 40 to >1000 fold selectivity against the remaining PIKKs tested; PI3K-alpha (IC50=0.85 μM), ATR (50% inhibition at 30 μM) and ATM (IC50>30 μM). The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG (human ether-a-go-go-related gene) ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3, IC50=0.63 μM)[1].
CC-115 hydrochloride shows good in vivo PK profiles across multiple species with 53%, 76% and ~100% oral bioavailability in mouse, rat and dog, respectively. CC-115 is tested at lower doses of 0.25, 0.5 and 1 mg/kg bid or 1 mg/kg qd, with observed corresponding tumor volume reductions of 46%, 57%, 66% and 57% respectively. CC-115 sustains inhibition though 24 hours. At the 1 mg/kg dose CC-115 shows significant inhibition at 1 and 3 hours, CC-115 demonstrating inhibition through 10 hours. CC-115 is evaluated using both once (qd) and twice (bid) daily dosing schedules[1].
References
[1]. Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-5608.
CC-115 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
CC-115 (hydrochloride) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1788 | 58 |
Supplier | Advantage |
---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
InvivoChem | 58 |
Aladdin Scientific | 58 |
TargetMol Chemicals Inc. | 58 |
Amadis Chemical Company Limited | 58 |
Haoyuan Chemexpress Co., Ltd. | 61 |
MedChemexpress LLC | 58 |
ShangHai Biochempartner Co.,Ltd | 62 |
Musechem | 60 |
Twochem Co.Ltd. | 58 |
View Lastest Price from CC-115 (hydrochloride) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-24 | CC-115 hydrochloride
1300118-55-1
|
US $1657.00 / mg | 10g | TargetMol Chemicals Inc. |
- CC-115 hydrochloride
1300118-55-1
- US $1657.00 / mg
- TargetMol Chemicals Inc.