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STING agonist-1

CAS No.
702662-50-8
Chemical Name:
STING agonist-1
Synonyms
STING agonist-1;STING agonist-1 (G10);4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide;2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-;inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING
CBNumber:
CB03067022
Molecular Formula:
C21H16ClFN2O3S
Molecular Weight:
430.88
MDL Number:
MOL File:
702662-50-8.mol
Last updated:2024-11-19 20:33:22

STING agonist-1 Properties

Boiling point 668.3±55.0 °C(Predicted)
Density 1.428±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 0.5 mg/ml
form A crystalline solid
pka 13.53±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

STING agonist-1 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22353 G10 ≥98% 702662-50-8 1mg $33 2024-03-01 Buy
Cayman Chemical 22353 G10 ≥98% 702662-50-8 5mg $107 2024-03-01 Buy
Cayman Chemical 22353 G10 ≥98% 702662-50-8 10mg $164 2024-03-01 Buy
Cayman Chemical 22353 G10 ≥98% 702662-50-8 25mg $438 2021-12-16 Buy
TRC G932043 G10 702662-50-8 2.5mg $165 2021-12-16 Buy
Product number Packaging Price Buy
22353 1mg $33 Buy
22353 5mg $107 Buy
22353 10mg $164 Buy
22353 25mg $438 Buy
G932043 2.5mg $165 Buy

STING agonist-1 Chemical Properties,Uses,Production

Description

G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.

Uses

G10 is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV).

storage

Store at -20°C

STING agonist-1 Preparation Products And Raw materials

Raw materials

Preparation Products

STING agonist-1 Suppliers

Global( 57)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30238 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Tianjin Derchemist Science & Technology Co., Ltd. 22-58627059 13920586291 zdcomcon@126.com China 3461 50

View Lastest Price from STING agonist-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
STING agonist-1 pictures 2024-11-19 STING agonist-1
702662-50-8
US $30.00-98.00 / mg 98.76% 10g TargetMol Chemicals Inc.
  • STING agonist-1 pictures
  • STING agonist-1
    702662-50-8
  • US $30.00-98.00 / mg
  • 98.76%
  • TargetMol Chemicals Inc.

STING agonist-1 Spectrum

STING agonist-1 STING agonist-1 (G10) 4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide 2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo- 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide inhibit,TMEM173,Inhibitor,STING agonist 1,G 10,G-10,Stimulator of Interferon Genes,STING agonist-1,MITA,MPYS,Virus Protease,ERIS,STING agonist1,STING 702662-50-8 API