diethyl 4-oxo-4H-pyran-2,5-dicarboxylate
- CAS No.
- 1246616-74-9
- Chemical Name:
- diethyl 4-oxo-4H-pyran-2,5-dicarboxylate
- Synonyms
- diethyl isochelidonate;diethyl 4-oxo-4H-pyran-2,5-dicarboxylate;4H-Pyran-2,5-dicarboxylic acid, 4-oxo-, 2,5-diethyl ester
- CBNumber:
- CB03106521
- Molecular Formula:
- C11H12O6
- Molecular Weight:
- 240.21
- MDL Number:
- MOL File:
- 1246616-74-9.mol
Last updated:2023-06-05 08:28:37
diethyl 4-oxo-4H-pyran-2,5-dicarboxylate Chemical Properties,Uses,Production
Uses
4-Oxo-4H-pyran-2,5-dicarboxylic Acid 2,5-Diethyl Ester is an intermediate used in the synthesis of Defluoro Dolutegravir (D228715), which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
![134653-70-6](/CAS/20150408/GIF/134653-70-6.gif)
![95-92-1](/CAS/GIF/95-92-1.gif)
![1246616-74-9](/CAS/20180629/GIF/1246616-74-9.gif)
Synthesis of diethyl 4-oxo-4H-pyran-2,5-dicarboxylate from Butanoic acid, 2-[(diMethylaMino)Methylene]-3-oxo-, ethyl ester,(2Z)- and Diethyl oxalate
diethyl 4-oxo-4H-pyran-2,5-dicarboxylate Preparation Products And Raw materials
diethyl 4-oxo-4H-pyran-2,5-dicarboxylate Suppliers
Global( 4)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
Alchemist-pharm chemical Technology Co. Ltd. | 0371-67991738 13783628208 | carl@alchemist-pharm.com | China | 1877 | 58 |
Shandong Shenganbei New Energy Co. , Ltd. . Nanjing branch | 18914494296 | sab202211@163.com | China | 1603 | 58 |
diethyl 4-oxo-4H-pyran-2,5-dicarboxylate
diethyl isochelidonate
4H-Pyran-2,5-dicarboxylic acid, 4-oxo-, 2,5-diethyl ester
1246616-74-9