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Selonsertib

CAS No.
1448428-04-3
Chemical Name:
Selonsertib
Synonyms
GS 4997;GS-4497;CS-2217;Selonsertib;GS-4997;ASK-1;GS4997;GS 4997;GS4997 SELONSERTIB;Selonsertib GS-4997;Selonsertib free base.;Selonsertib (Synonyms: GS-4997)
CBNumber:
CB03122039
Molecular Formula:
C24H24FN7O
Molecular Weight:
445.49
MDL Number:
MFCD29920355
MOL File:
1448428-04-3.mol
Last updated:2024-11-20 17:10:19

Selonsertib Properties

Melting point >180°C (dec.)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
pka 11.21±0.70(Predicted)
form solid
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey YIDDLAAKOYYGJG-UHFFFAOYSA-N
SMILES C(NC1=NC(C2N(C(C)C)C=NN=2)=CC=C1)(=O)C1=CC(N2C=NC(C3CC3)=C2)=C(C)C=C1F
CAS DataBase Reference 1448428-04-3
FDA UNII NS3988A2TC

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H373
Precautionary statements  P260-P314-P501
NFPA 704
0
2 0

Selonsertib price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20972 Selonsertib ≥95% 1448428-04-3 500μg $32 2024-03-01 Buy
Cayman Chemical 20972 Selonsertib ≥95% 1448428-04-3 1mg $57 2024-03-01 Buy
Cayman Chemical 20972 Selonsertib ≥95% 1448428-04-3 5mg $214 2024-03-01 Buy
Cayman Chemical 20972 Selonsertib ≥95% 1448428-04-3 10mg $335 2024-03-01 Buy
TRC S253800 Selonsertib 1448428-04-3 10mg $315 2021-12-16 Buy
Product number Packaging Price Buy
20972 500μg $32 Buy
20972 1mg $57 Buy
20972 5mg $214 Buy
20972 10mg $335 Buy
S253800 10mg $315 Buy

Selonsertib Chemical Properties,Uses,Production

Description

Selonsertib (1448428-04-3) is a potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3)1 found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis2-4. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and ABCG2.5

Uses

Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated.

in vitro

gs-4997 has been identified as a highly selective and potent ask1 inhibitor that competed with atp in the ask1 catalytic kinase domain. moreover, the ask1 inhibition caused by gs-4997 was found to be significantly different in mechanism from bardoxolone methyl. gs- 4997 could also shut down cell signaling involved in pathogenesis, while bardoxolone methyl activated mrna transcription in every cell exposed to drug. in addition, gs-4997 could selectively target affected cells in which the oxidative burden was high [1].

References

Lanier et al. (2017), Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure; ACS Med. Chem. Lett. 8 316 Loomba et al. (2017), The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial; Hepatology 67 549 Younossi et al. (2018), Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib; Liver Int. 38 1849 Gawrieh and Chalasani (2018), Emerging Treatments for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis; Clin. Liver Dis. 22 189 Ji et al. (2019), Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells; Cancer Lett. 440-441 82

Selonsertib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 131)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338 stella@zetchem.com China 2136 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795 info@shochem.com CHINA 288 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58

View Lastest Price from Selonsertib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Selonsertib pictures 2024-11-19 Selonsertib
1448428-04-3
US $33.00-93.00 / mg 99.53% 10g TargetMol Chemicals Inc.
Selonsertib pictures 2019-12-23 Selonsertib
1448428-04-3
US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co
Selonsertib pictures 2019-07-06 Selonsertib
1448428-04-3
US $10.00 / KG/Tin 1KG/Tin 99% 100 Career Henan Chemical Co
  • Selonsertib pictures
  • Selonsertib
    1448428-04-3
  • US $33.00-93.00 / mg
  • 99.53%
  • TargetMol Chemicals Inc.
  • Selonsertib pictures
  • Selonsertib
    1448428-04-3
  • US $9.80 / KG
  • ≥99%
  • Career Henan Chemical Co
  • Selonsertib pictures
  • Selonsertib
    1448428-04-3
  • US $10.00 / KG/Tin
  • 99%
  • Career Henan Chemical Co

Selonsertib Spectrum

Selonsertib 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide Selonsertib GS-4997 GS-4497 GS-4997;ASK-1 GS4997 SELONSERTIB 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Selonsertib (Synonyms: GS-4997) Selonsertib free base. GS-4997; GS4997; GS 4997; SELONSERTIB FREE BASE. GS4997;GS 4997 CS-2217 GS 4997 1448428-04-3 C24H24FN7O API