FITM
- CAS No.
- 932737-65-0
- Chemical Name:
- FITM
- Synonyms
- FITM;FITM, 10 mM in DMSO;FITM,mGluR,Metabotropic glutamate receptors,inhibit,Inhibitor;4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide;4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide;4-fluoro-N-methyl-N-[4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]benzamide;Benzamide, 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]-
- CBNumber:
- CB03133226
- Molecular Formula:
- C18H18FN5OS
- Molecular Weight:
- 371.43
- MDL Number:
- MOL File:
- 932737-65-0.mol
FITM price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29219 | FITM | 932737-65-0 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29219 | FITM | 932737-65-0 | 25mg | $381 | 2024-03-01 | Buy |
| Cayman Chemical | 29219 | FITM | 932737-65-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29219 | FITM | 932737-65-0 | 10mg | $169 | 2024-03-01 | Buy |
| Tocris | 6859 | FITM ≥98%(HPLC) | 932737-65-0 | 50 | $609 | 2021-12-16 | Buy |
FITM Chemical Properties,Uses,Production
Uses
4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide is a potent mGluR1 antagonist. It also demonstrats a relatively potent antipyschotic-like effect in several animal models, suitable for the development of a PET tracer.
in vivo
The pretreatment of rats with unlabeled FITM (1 mg/kg) occupies an mGluR1 binding site of 18F-FITM by more than 99% and does not affect the input function. The Kd (nM) and Bmax (pmol/mL) obtained by the Scatchard analyses with the multidose ligand assays are 2.1 and 36.3, respectively, for the thalamus; 2.1 and 27.5, respectively, for the hippocampus; 1.5 and 22.2, respectively, for the striatum; and 1.5 and 20.5, respectively, for the cingulate cortex with a high confidence[3]. 18F-FITM shows excellent pharmacokinetics, namely the dense and specific accumulation in mGlu1-positive melanomas versus mGlu1-negative hepatoma and normal tissues. Furthermore, the accumulation levels of radioactivity corresponded to the extent of tumor and to levels of mGlu1 protein expression in melanomas and melanoma metastasis[4].
IC 50
mGlu1: 2.5 nM (Ki)
storage
Store at -20°C
FITM Preparation Products And Raw materials
Raw materials
Preparation Products
FITM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 18626450290 | yftan@aikonchem.com | China | 16684 | 50 |
