ChemicalBook >> CAS DataBase List >>NS-018 (maleate)
NS-018 (maleate)
- CAS No.
- 1354799-87-3
- Chemical Name:
- NS-018 (maleate)
- Synonyms
- NS-018 (maleate);Ilginatinib maleate;NS018 MALEATE;ILGINATINIB MALEATE;ILGINATINIB (MALEATE) (NS-018 (MALEATE));(S)-N2-(1-(4-Fluorophenyl)ethyl)-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate;Inhibitor,JAK3,NS 018,inhibit,JAK2,Ilginatinib,bioavailable,NS018,orally,Ilginatinib maleate,NS-018,JAK1,Janus kinase,JAK,Tyk2
- CBNumber:
- CB03137709
- Molecular Formula:
- C25H24FN7O4
- Molecular Weight:
- 505.5009632
- MDL Number:
- MOL File:
- 1354799-87-3.mol
Last updated:2024-07-02 08:54:57
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : ≥ 30 mg/mL (59.35 mM) |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | 8P0KTT2T1Z |
NS-018 (maleate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5784 | Ilginatinibmaleate 97.04% | 1354799-87-3 | 5mg | $285 | 2021-12-16 | Buy |
| ChemScene | CS-5784 | Ilginatinibmaleate 97.04% | 1354799-87-3 | 10mg | $395 | 2021-12-16 | Buy |
| ChemScene | CS-5784 | Ilginatinibmaleate 97.04% | 1354799-87-3 | 25mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-5784 | Ilginatinibmaleate 97.04% | 1354799-87-3 | 50mg | $870 | 2021-12-16 | Buy |
| ChemScene | CS-5784 | Ilginatinibmaleate 97.04% | 1354799-87-3 | 100mg | $1250 | 2021-12-16 | Buy |
NS-018 (maleate) Chemical Properties,Uses,Production
Biological Activity
Ilginatinib maleate (NS-018 maleate) is a highly potent, orally available JAK2 inhibitor with IC50 of 0.72 nM, 46-fold selectivity for JAK1 (IC50, 33 nM) and 54-fold for JAK3 ( IC50, 39 nM), and 22 times that of Tyk2 (IC50, 22 nM).
in vivo
Ilginatinib maleate (NS-018 maleate) (12.5, 25, 50, 100 mg/kg, p.o.) potently prolongs the survival of mice and reduces splenomegaly in a mouse Ba/F3-JAK2V617F disease model.
target
| JAK2 0.72 nM (IC 50 ) | Tyk2 22 nM (IC 50 ) | JAK1 33 nM (IC 50 ) | JAK3 39 nM ( IC 50 ) |
NS-018 (maleate) Preparation Products And Raw materials
Raw materials
Preparation Products
NS-018 (maleate) Suppliers
Global( 21)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9772 | 58 |
NS-018 (maleate)
Ilginatinib maleate
NS018 MALEATE;ILGINATINIB MALEATE
ILGINATINIB (MALEATE) (NS-018 (MALEATE))
Inhibitor,JAK3,NS 018,inhibit,JAK2,Ilginatinib,bioavailable,NS018,orally,Ilginatinib maleate,NS-018,JAK1,Janus kinase,JAK,Tyk2
(S)-N2-(1-(4-Fluorophenyl)ethyl)-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate
1354799-87-3