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ChemicalBook >> CAS DataBase List >>4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Structure
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile structure
CAS No.
1399177-37-7
Chemical Name:
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile
Synonyms
TVB-2640;TVB2640;ASC40;ASC 40;ASC-40;EOS-61292;FASN-IN-2;Denifanstat;FASN inhibitor 2;TVB-2640(FASN-IN-2)
CBNumber:
CB03142727
Molecular Formula:
C27H29N5O
Molecular Weight:
439.55
MDL Number:
MOL File:
1399177-37-7.mol
Last updated:2025-04-17 18:22:24
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4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Properties

Boiling point 708.3±70.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
solubility DMSO: soluble
form A solid
pka 9.96±0.40(Predicted)
color White to off-white
FDA UNII 4GF95B2LZA

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0066310 FASN-IN-2 98.52% 1399177-37-7 5mg $350 2021-12-16 Buy
ChemScene CS-0066310 FASN-IN-2 98.52% 1399177-37-7 10mg $550 2021-12-16 Buy
ChemScene CS-0066310 FASN-IN-2 98.52% 1399177-37-7 50mg $1500 2021-12-16 Buy
DC Chemicals DC26189 TVB-2640 1399177-37-7 250mg $1700 2021-12-16 Buy
DC Chemicals DC26189 TVB-2640 1399177-37-7 100mg $950 2021-12-16 Buy
Product number Packaging Price Buy
CS-0066310 5mg $350 Buy
CS-0066310 10mg $550 Buy
CS-0066310 50mg $1500 Buy
DC26189 250mg $1700 Buy
DC26189 100mg $950 Buy

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Chemical Properties,Uses,Production

Uses

Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research[1][2].

References

[1] Minhyoung Lee, et al. Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 Spike Protein and improves survival of mice infected with murine hepatitis virus. BioRxiv, December 21, 2020.
[2] Johan D., et al. Heterocyclic modulators of lipid synthesis. WO2012122391A1.

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Guangzhou Tosun Pharmaceutical Limited 		+8618922120635 sales@toref-standards.com China 998 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 17702719238 sales@sun-shinechem.com China 1006 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 310 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Guangzhou Tosun Pharmaceutical Limited 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai XingMo Biotechnology Co., Ltd. 55
4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile Benzonitrile, 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]- FASN inhibitor 2 FASN-IN-2 EOS-61292 TVB-2640 TVB2640 Denifanstat Denifanstat (TVB-2640) SARS-CoV2,ASC40,Denifanstat,TVB 2640,Inhibitor,spike,inhibit,ASC 40,Fatty Acid Synthase (FASN),protein,COVID-19,ASC-40 TVB-2640(FASN-IN-2) ASC 40 ASC40 ASC-40 4-(1-(4-Cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile Denifanstat, 10 mM in DMSO 1399177-37-7 TVB2640