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ChemicalBook >> CAS DataBase List >>5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one Structure
5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one structure
CAS No.
1446090-79-4
Chemical Name:
5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
Synonyms
EOS-60483;Lifirafenib;Beigene-283;BGB-283;BEIGENE-283;5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one;1,8-Naphthyridin-2(1H)-one, 5-[[(1R,1aS,6bR)-1a,6b-dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro-
CBNumber:
CB03142792
Molecular Formula:
C25H17F3N4O3
Molecular Weight:
478.42
MDL Number:
MFCD30489379
MOL File:
1446090-79-4.mol
Last updated:2024-07-02 08:54:57
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5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one Properties

Boiling point 651.9±65.0 °C(Predicted)
Density 1.72±0.1 g/cm3(Predicted)
solubility DMSO:97.5(Max Conc. mg/mL);203.79(Max Conc. mM)
Ethanol:95.0(Max Conc. mg/mL);198.57(Max Conc. mM)
pka 10.16±0.10(Predicted)
form Solid
color White to off-white
FDA UNII 8762XZS5ZF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-6308 Lifirafenib 98.02% 1446090-79-4 50mg $648 2021-12-16 Buy
Biorbyt Ltd orb573381 Lifirafenib >98% 1446090-79-4 100mg $838.1 2021-12-16 Buy
ChemScene CS-6308 Lifirafenib 98.02% 1446090-79-4 100mg $1008 2021-12-16 Buy
ChemScene CS-6308 Lifirafenib 98.02% 1446090-79-4 5mg $156 2021-12-16 Buy
ChemScene CS-6308 Lifirafenib 98.02% 1446090-79-4 10mg $216 2021-12-16 Buy
Product number Packaging Price Buy
CS-6308 50mg $648 Buy
orb573381 100mg $838.1 Buy
CS-6308 100mg $1008 Buy
CS-6308 5mg $156 Buy
CS-6308 10mg $216 Buy

5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one Chemical Properties,Uses,Production

Uses

Lifirafenib it is quinoline derivative used for combination treatment of small cell lung cancer.

5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6008 61
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4197 55
Jinan elephant international trading co., LTD 13006575422@163.com China 6357 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@tcypharm.com China 595 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Chembest Research Laboratories Limited 61
Shanghai Lollane Biological Technology Co.,Ltd. 55
Jinan elephant international trading co., LTD 58
Kaixin Chemical (Hong Kong) Limited 55
5-((1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one EOS-60483 Lifirafenib BGB-283;BEIGENE-283 Beigene-283 1,8-Naphthyridin-2(1H)-one, 5-[[(1R,1aS,6bR)-1a,6b-dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro- 1446090-79-4 C25H17F3N4O3