Acumapimod (BCT-197)
- CAS No.
- 836683-15-9
- Chemical Name:
- Acumapimod (BCT-197)
- Synonyms
- BCT-197;CS-2801;BCT-197-A2201;Acumapimod (BCT-197);Ixazomib Impurity 62;Acumapimod, 10 mM in DMSO;inhibit,p38 MAPK,BCT197,BCT 197,Acumapimod,Inhibitor,Autophagy;3-(5-Amino-4-(3-cyanobenzoyl)pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide;3-(5-Amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide;Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl-
- CBNumber:
- CB03147661
- Molecular Formula:
- C22H19N5O2
- Molecular Weight:
- 385.42
- MDL Number:
- MFCD28902244
- MOL File:
- 836683-15-9.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO:50.0(Max Conc. mg/mL);129.73(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| FDA UNII | 2F16KW647L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H318-H334-H335-H341-H361-H370-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340+P312-P305+P351+P338-P310-P321-P333+P313-P362-P403+P233-P405-P501 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Acumapimod (BCT-197) price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25832 | Acumapimod | 836683-15-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 25832 | Acumapimod | 836683-15-9 | 5mg | $145 | 2024-03-01 | Buy |
| Cayman Chemical | 25832 | Acumapimod | 836683-15-9 | 10mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 25832 | Acumapimod | 836683-15-9 | 25mg | $645 | 2024-03-01 | Buy |
| ChemScene | CS-6195 | Acumapimod 99.03% | 836683-15-9 | 50mg | $450 | 2021-12-16 | Buy |
Acumapimod (BCT-197) Chemical Properties,Uses,Production
Uses
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
in vivo
Acumapimod is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of Acumapimod (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2].
References
[1] Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. DOI:10.1517/13543784.2014.918604
[2] De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700. DOI:10.1002/psp4.12037
Acumapimod (BCT-197) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4966 | 55 |
View Lastest Price from Acumapimod (BCT-197) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-29 | Acumapimod
836683-15-9
|
US $30.00-98.00 / mg | ≥95% | 10g | TargetMol Chemicals Inc. |
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- Acumapimod
836683-15-9
- US $30.00-98.00 / mg
- ≥95%
- TargetMol Chemicals Inc.