3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- CAS No.
- 70678-95-4
- Chemical Name:
- 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- Synonyms
- HO-PEG4-CH2COOH;Hydroxy-PEG4-CH2CO2H;Hydroxy-PEG4-CH2CO2H, sodium salt;14-hydroxy-3,6,9,12-tetraoxatetradecanoic acid;3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-;2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]aceticacid;HO-PEG4-CH2COOH/3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- CBNumber:
- CB03245444
- Molecular Formula:
- C10H20O7
- Molecular Weight:
- 252.26
- MDL Number:
- MFCD30730373
- MOL File:
- 70678-95-4.mol
- MSDS File:
- SDS
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- price
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Chemical Properties,Uses,Production
Description
Hydroxy-PEG4-CH2CO2H, sodium salt, is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Uses
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Suppliers
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