2-(3-sulfanylpropyl)pentanedioic acid
- CAS No.
- 254737-29-6
- Chemical Name:
- 2-(3-sulfanylpropyl)pentanedioic acid
- Synonyms
- 2-MPPA;2MPPA,2 MPPA;FNLNSQHJKVQCBP-UHFFFAOYSA-N;2-(3-Mercaptopropyl)pentanedioic acid;2-(3-sulfanylpropyl)pentanedioic acid;Pentanedioic acid, 2-(3-mercaptopropyl)-
- CBNumber:
- CB03313172
- Molecular Formula:
- C8H14O4S
- Molecular Weight:
- 206.26
- MDL Number:
- MOL File:
- 254737-29-6.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| form | Powder |
| color | Colorless to light yellow |
| FDA UNII | TV8F3S5KLG |
2-(3-sulfanylpropyl)pentanedioic acid price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5033 | 2-MPPA | 254737-29-6 | 10 | $202 | 2021-12-16 | Buy |
| Usbiological | 254369 | 2-MPPA | 254737-29-6 | 10mg | $522 | 2021-12-16 | Buy |
| TRC | M745810 | 2-MPPA | 254737-29-6 | 100mg | $1470 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 71639 | 2-MPPA | 254737-29-6 | 10mg | $675 | 2021-12-16 | Buy |
| ApexBio Technology | B7734 | 2-MPPA | 254737-29-6 | 10mg | $345 | 2021-12-16 | Buy |
2-(3-sulfanylpropyl)pentanedioic acid Chemical Properties,Uses,Production
Uses
2-MPPA is a selective glutamate carboxypeptidase II (GCP-II) inhibitor used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties.
in vivo
2-MPPA (10, 30 or 100 mg/kg) significantly attenuates Dizocilpine (HY-15084B) (0.1 mg/kg)-induced prepulse inhibition (PPI) deficits in mice, in a dose dependent manner. The efficacy of 2-MPPA on dizocilpine-induced PPI deficits is significantly antagonized by pretreatment with the selective group II metabotropic glutamate receptor (mGluR) antagonist LY341495 (HY-70059) (1.0 mg/kg)[1].
2-MPPA (30 mg/kg) significantly prevents the deficit in SNCV induced by both 5 and 25 mg/kg taxol by 96.3 ± 4.4% and 98.3± 11.6% respectively[2].
2-MPPA (10 mg/kg) inhibits tumor growth in the high expressor PSMA model CWR22RS by 70%[2].
2-(3-sulfanylpropyl)pentanedioic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3-sulfanylpropyl)pentanedioic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd. | 17752881701 | 190060276@qq.com | China | 161 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
