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G1T28

G1T28 Structure
G1T28 structure
CAS No.
1977495-97-8
Chemical Name:
G1T28
Synonyms
G1T28;Trilaciclib HCl;Trilaciclib DiHCl;G1T28 hydrochloride;Trasylide hydrochloride;Trilaciclib hydrochloride;Trilaciclib dihydrochloride;Trilaciclib hydrochloride(G1T28);Trilaciclib Impurity(Dihydrochloride);Inhibitor,Trilaciclib hydrochloride,CDK,Cyclin dependent kinase,inhibit,Trilaciclib,G1T28
CBNumber:
CB03335415
Molecular Formula:
C24H31ClN8O
Molecular Weight:
483.02
MDL Number:
MFCD31630829
MOL File:
1977495-97-8.mol
Last updated:2025-04-18 09:51:34
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G1T28 Properties

storage temp. Store at -20°C
form Solid
color Light yellow to yellow
Water Solubility Water : ≥ 100 mg/mL (192.50 mM)
FDA UNII 4BX07W725T

G1T28 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-7942 Trilaciclib(hydrochloride) 99.24% 1977495-97-8 5mg $700 2021-12-16 Buy
ChemScene CS-7942 Trilaciclib(hydrochloride) 99.24% 1977495-97-8 10mg $950 2021-12-16 Buy
ChemScene CS-7942 Trilaciclib(hydrochloride) 99.24% 1977495-97-8 100mg $2400 2021-12-16 Buy
DC Chemicals DC21033 Trilaciclibhydrochloride(G1T28) >98% 1977495-97-8 250mg $1500 2021-12-16 Buy
DC Chemicals DC21033 Trilaciclibhydrochloride(G1T28) >98% 1977495-97-8 100mg $800 2021-12-16 Buy
Product number Packaging Price Buy
CS-7942 5mg $700 Buy
CS-7942 10mg $950 Buy
CS-7942 100mg $2400 Buy
DC21033 250mg $1500 Buy
DC21033 100mg $800 Buy

G1T28 Chemical Properties,Uses,Production

Uses

Trilaciclib (G1T28) hydrochloride is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib hydrochloride can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib hydrochloride attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1].

in vivo

Trilaciclib hydrochloride (50-150 mg/kg; po; single dose) protects mouse bone marrow cells from chemotherapy-induced apoptosis and attenuates chemotherapy-induced myelosuppression in vivo. Trilaciclib hydrochloride at 150 mg/kg reduces HSPC damage induced by 5FU (150 mg/kg; ip) chemotherapy, thereby accelerating blood count recovery after chemotherapy[1].

Animal Model:FVB/n female C57Bl6 mice[1]
Dosage:50, 100, 150 mg/kg
Administration:Po; single dose; treated followed 11 or 23 hours later by a single injection of EdU (HY-118411) (100 μg; ip); mouse were euthanized 1 hour after EdU injection.
Result:Showed a dose-dependent decrease in caspase 3/7 activation.
Attenuated chemotherapy-induced myelosuppression in mice.

IC 50

Cdk4/cyclin D1: 1 nM (IC50); cdk6/cyclin D3: 4 nM (IC50)

References

[1] Bisi JE, et al. Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression. Mol Cancer Ther. 2016 May;15(5):783-93. DOI:10.1158/1535-7163.MCT-15-0775

G1T28 Preparation Products And Raw materials

Raw materials

Preparation Products

G1T28 Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Wuhan Demeikai Biotechnology Co., Ltd 		+8618942921723 info@dmksw.xin China 717 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
BTC pharm India 		+918790379245 banny.janga@btcpharm.com India 1262 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Shanghai Guangyang Jiali Biotechnology Co., Ltd 		13407521611 46993711@qq.com China 176 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39003 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Supplier Advantage
Jinan Carbotang Biotech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Demeikai Biotechnology Co., Ltd 		58
InvivoChem 		58
BTC pharm India 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Shanghai Guangyang Jiali Biotechnology Co., Ltd 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58

View Lastest Price from G1T28 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trilaciclib hydrochloride pictures 2024-11-19 Trilaciclib hydrochloride
1977495-97-8
 US $31.00-163.00 / mg 99.69% 10g TargetMol Chemicals Inc.
Trilaciclib hydrochloride pictures 2024-11-19 Trilaciclib hydrochloride
1977495-97-8
 US $31.00-163.00 / mg 99.69% 10g TargetMol Chemicals Inc.

G1T28 Spectrum

G1T28(1977495-97-8)1HNMR
G1T28 Trilaciclib HCl Trilaciclib hydrochloride G1T28 hydrochloride 2'-[[5-(4-Methylpiperazin-1-yl)pyridin-2-yl]amino}-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one, hydrochloride (1:2) Trilaciclib hydrochloride(G1T28) Trilaciclib dihydrochloride 2'-((5-(4-Methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one dihydrochloride Inhibitor,Trilaciclib hydrochloride,CDK,Cyclin dependent kinase,inhibit,Trilaciclib,G1T28 12'-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-2',5',11',13'-tetraazaspiro[cyclohexane-1,3'-tricyclo[7.4.0.02,?]tridecane]-1'(9'),7',10',12'-tetraen-6'-one dihydrochloride Trasylide hydrochloride Trilaciclib DiHCl Trilaciclib Impurity(Dihydrochloride) 1977495-97-8