ChemicalBook >> CAS DataBase List >>PF04191834
PF04191834
- CAS No.
- 1029317-21-2
- Chemical Name:
- PF04191834
- Synonyms
- PF-4191834;PF04191834;PF-4191834 >=98% (HPLC);PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor;2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-
- CBNumber:
- CB03354232
- Molecular Formula:
- C22H23N3O2S
- Molecular Weight:
- 393.5
- MDL Number:
- MOL File:
- 1029317-21-2.mol
Last updated:2024-11-19 15:53:33
| Melting point | 173 °C |
|---|---|
| Boiling point | 663.0±55.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 15.78±0.20(Predicted) |
| color | White to yellow |
| FDA UNII | YX55DXP4T1 |
PF04191834 Chemical Properties,Uses,Production
Biological Activity
PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain.
in vitro
PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM.
target
| 5-LOX < span> |
PF04191834 Preparation Products And Raw materials
Raw materials
Preparation Products
PF04191834 Suppliers
Global( 15)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29785 | 68 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44807 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9475 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29979 | 58 |
View Lastest Price from PF04191834 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | PF-4191834
1029317-21-2
|
US $48.00-157.00 / mg | 99.77% | 10g | TargetMol Chemicals Inc. |
-
- PF-4191834
1029317-21-2
- US $48.00-157.00 / mg
- 99.77%
- TargetMol Chemicals Inc.
1029317-21-2(PF04191834)Related Search:
PF04191834
PF-4191834
2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-
PF-4191834 >=98% (HPLC)
PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor
1029317-21-2