AX-024 hcl
- CAS No.
- 1370544-73-2
- Chemical Name:
- AX-024 hcl
- Synonyms
- CS-2619;AX-024 hcl;AX 024;AX024;1-((4-(4-FLUOROPHENYL)-6-METHOXY-2H-CHROMEN-3-YL)METHYL)PYRROLIDINE;Pyrrolidine, 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-
- CBNumber:
- CB03357970
- Molecular Formula:
- C21H22FNO2
- Molecular Weight:
- 339.4
- MDL Number:
- MOL File:
- 1370544-73-2.mol
Boiling point | 452.0±45.0 °C(Predicted) |
---|---|
Density | 1.201±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility |
DMSO:35.0(Max Conc. mg/mL);103.12(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);294.63(Max Conc. mM) |
pka | 9.26±0.20(Predicted) |
form | Solid |
color | Light yellow to yellow |
AX-024 hcl price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A965390 | AX-024 | 1370544-73-2 | 5mg | $230 | 2021-12-16 | Buy |
TRC | A965390 | AX-024 | 1370544-73-2 | 1mg | $65 | 2021-12-16 | Buy |
ChemScene | CS-8052 | AX-024 ≥98.0% | 1370544-73-2 | 2mg | $120 | 2021-12-16 | Buy |
ChemScene | CS-8052 | AX-024 ≥98.0% | 1370544-73-2 | 5mg | $180 | 2021-12-16 | Buy |
ChemScene | CS-8052 | AX-024 ≥98.0% | 1370544-73-2 | 100mg | $1980 | 2021-12-16 | Buy |
AX-024 hcl Chemical Properties,Uses,Production
Description
AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation. AX-024 modulates cell signaling by targeting SH3 domains and has low-acute toxicity and high potency and selectivity in the inhibition of the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
Uses
AX-024, is >10,000-fold more potent than the AX-000 hit in terms of inhibition of TCR-triggered T cell proliferation. It is a cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
in vitro
AX-024 reduces T cell proliferation upon weak T cell receptor (TCR) stimulation but neither significantly affects phosphorylation of Zap70 (ζ chain of T cell receptor–associated protein kinase 70) nor interacts directly with Nck1-SH3. AX-024 is likely not involved in modulating the Nck/TCR interaction but probably has other targets in T cells. An array of biophysical techniques did not detect a direct interaction between AX-024 and Nck-SH3.1 in vitro._x000D_ _x000D_ Reference: J Biol Chem. 2020 Jun 5;295(23):7849-7864. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278359/#B11
target
AX-024 is an inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.
AX-024 hcl Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4287 | 55 | |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 | dexuanpharma@126.com | China | 9478 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Anqing Rong Chuang Biological Technology Co., Ltd. | 15001988657 | 1367753897@qq.com | China | 955 | 58 |