Labeled d8 Desmethyl Clozapine Hydrochloride
- CAS No.
- 1189888-77-4
- Chemical Name:
- Labeled d8 Desmethyl Clozapine Hydrochloride
- Synonyms
- [2H8]-N-Desmethyl Clozapine;Labeled d8 Desmethyl Clozapine Hydrochloride;N-DESMETHYLCLOZAPINE (D8, 98%) 100 UG/ML IN METHANOL;6-chloro-10-[(2,2,3,3,5,5,6,6-2H?)piperazin-1-yl]-2,9-diazatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
- CBNumber:
- CB03567643
- Molecular Formula:
- C17H17ClN4
- Molecular Weight:
- 312.8
- MDL Number:
- MFCD09840368
- MOL File:
- 1189888-77-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Labeled d8 Desmethyl Clozapine Hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26027 | N-Desmethylclozapine-d8 | 1189888-77-4 | 500μg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 26027 | N-Desmethylclozapine-d8 | 1189888-77-4 | 1mg | $171 | 2024-03-01 | Buy |
| TRC | D292002 | N-DesmethylClozapine-d8 | 1189888-77-4 | 1mg | $175 | 2021-12-16 | Buy |
| TRC | D292002 | N-DesmethylClozapine-d8 | 1189888-77-4 | 10mg | $1355 | 2021-12-16 | Buy |
| AK Scientific | 6414EM | N-DesmethylClozapine-d8 | 1189888-77-4 | 1mg | $287 | 2021-12-16 | Buy |
Labeled d8 Desmethyl Clozapine Hydrochloride Chemical Properties,Uses,Production
Uses
A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.
Biological Activity
N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine .1 It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.2,3 N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.3,1,4 N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.5
References
1.Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3)1278-1287(2005) 2.Kuoppam?ki, M., Syv?lahti, E., and Hietala, J.Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonistsEur. J. Pharmacol.245(2)179-182(1993) 3.Lameh, J., Burstein, E.S., Taylor, E., et al.Pharmacology of N-desmethylclozapinePharmacol. Ther.115(2)223-231(2007) 4.Odagaki, Y., Kinoshita, M., and Ota, T.Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranesJ. Psychopharmacol.30(9)896-912(2016) 5.Maehara, S., Hikichi, H., and Ohta, H.Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptorsBrain Res.1418111-119(2011)
Labeled d8 Desmethyl Clozapine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Labeled d8 Desmethyl Clozapine Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Artis Biotech Co. Ltd. | 0575-0575-18780151478 18582380095 | sales@artisbio.com | China | 3213 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9805 | 58 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2325 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44807 | 58 |
| Manhag Testing Technology Co., Ltd | 020-020-3846236 17688849268 | 2443244976@qq.com | China | 7775 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 17730 | 58 |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9376 | 58 |
| Henan Vcommend Consultrading Co., Ltd. | 13393721940; 13393721940 | sales@vcommend.com | China | 10005 | 58 |
View Lastest Price from Labeled d8 Desmethyl Clozapine Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | N-Desmethyl clozapine-d8
1189888-77-4
|
US $267.00-0.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- N-Desmethyl clozapine-d8
1189888-77-4
- US $267.00-0.00 / mg
- TargetMol Chemicals Inc.