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Acetyl tributyl citrate

Acetyl tributyl citrate Structure
Acetyl tributyl citrate structure
CAS No.
77-90-7
Chemical Name:
Acetyl tributyl citrate
Synonyms
ATBC;TRIBUTYL ACETYLCITRATE;Acetyltributylcitrat;TRIBUTYL O-ACETYLCITRATE;Tributyl citrate acetate;citroflexa4;Acetyl butyl citrate;tributylcitrateacetate;ACETYL TRI-N-BUTYL CITRATE;tributyl 2-acetoxypropane-1,2,3-tricarboxylate
CBNumber:
CB0408022
Molecular Formula:
C20H34O8
Molecular Weight:
402.48
MDL Number:
MFCD00043554
MOL File:
77-90-7.mol
MSDS File:
SDS
Last updated:2024-10-30 18:52:02
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Acetyl tributyl citrate Properties

Melting point -59 °C
Boiling point 327 °C
Density 1.05 g/mL at 25 °C (lit.)
Pour Point -43
vapor pressure 0.26 psi ( 20 °C)
refractive index n20/D 1.443(lit.)
FEMA 3080 | TRIBUTYL ACETYLCITRATE
Flash point >230 °F
storage temp. Store below +30°C.
solubility Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
form Liquid
color Clear Colourless
Odor at 100.00 %. very faint herbal wine sweet
Odor Type herbal
Viscosity 32.7cp (25C)
Water Solubility <0.1 g/100 mL
FreezingPoint -80℃
JECFA Number 630
BRN 2303316
InChIKey QZCLKYGREBVARF-UHFFFAOYSA-N
LogP 5.227 (est)
CAS DataBase Reference 77-90-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) TRIBUTYL ACETYLCITRATE
FDA 21 CFR 172.515; 175.105; 175.300; 175.320; 181.27
EWG's Food Scores 1
FDA UNII 0ZBX0N59RZ
NIST Chemistry Reference 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA Substance Registry System Acetyl tributyl citrate (77-90-7)
Cosmetics Info Acetyl Tributyl Citrate

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
RTECS  TZ8330000
TSCA  TSCA listed
HS Code  29181500
NFPA 704
1
0 0

Acetyl tributyl citrate price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1009901 Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard 77-90-7 500mg $450 2022-05-15 Buy
TCI Chemical A0822 Tributyl O-Acetylcitrate >97.0%(GC) 77-90-7 25mL $17 2024-03-01 Buy
TCI Chemical A0822 Tributyl O-Acetylcitrate >97.0%(GC) 77-90-7 500mL $54 2024-03-01 Buy
scipoly P-107 Acetyl tri-n-butyl citrate 77-90-7 100g $14 2024-07-03 Buy
scipoly P-107 Acetyl tri-n-butyl citrate 77-90-7 250g $28 2024-07-03 Buy
Product number Packaging Price Buy
1009901 500mg $450 Buy
A0822 25mL $17 Buy
A0822 500mL $54 Buy
P-107 100g $14 Buy
P-107 250g $28 Buy

Acetyl tributyl citrate Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Uses

plasticizer flavoring agent

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

Definition

Aqueous-based pharmaceutical coat- ings.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

Preparation

From citric acid via the tributyl ester followed by acetylation.

Taste threshold values

An emulsion of the title material in water at 1000 ppm has only a very faint, mildly fruity-winey, berry-like odor and a mild, nondescript taste.

General Description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

Solubility in organics

Miscible with alcohol and oils.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Acetyl tributyl citrate Preparation Products And Raw materials

Raw materials

1-Butanol Citric acid

Preparation Products

Acetyl tributyl citrate Suppliers

Global( 505)Suppliers
Supplier Tel Email Country ProdList Advantage
Changyi Longchang Bio-Chemical Co., LTD 		+8613256193735 info@longchangchemical.com China 990 58
Anhui Royal Chemical Co., Ltd. 		+86-25-86655873 +8613962173137 marketing@royal-chem.com China 193 55
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8812 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5893 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18154 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20287 58
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@sdzhonghuimaterial.com China 983 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3002 58
Shandong Deshang Chemical Co., Ltd. 		+86-0531-8875-2665 +8613153039501 info@deshangchem.com China 662 58
Supplier Advantage
Changyi Longchang Bio-Chemical Co., LTD 		58
Anhui Royal Chemical Co., Ltd. 		55
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Weibang Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
airuikechemical co., ltd. 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Shandong Deshang Chemical Co., Ltd. 		58

Related articles

View Lastest Price from Acetyl tributyl citrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ACETYL TRIBUTYL CITRATE pictures 2024-11-22 ACETYL TRIBUTYL CITRATE
77-90-7
 US $770.00 / kg 1000kg 99% 20 tons Anhui Royal Chemical Co., Ltd.
Acetyl tributyl citrate pictures 2024-11-22 Acetyl tributyl citrate
77-90-7
 US $100.00 / kg 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co.,Ltd
butyl acetylcitrate pictures 2024-11-22 butyl acetylcitrate
77-90-7
 US $60.00 / kg 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co.,Ltd

Acetyl tributyl citrate Spectrum

Acetyl tributyl citrate(77-90-7)MSAcetyl tributyl citrate(77-90-7)1HNMRAcetyl tributyl citrate(77-90-7)13CNMRAcetyl tributyl citrate(77-90-7)IR1Acetyl tributyl citrate(77-90-7)Raman

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