Acetyl tributyl citrate
- CAS No.
- 77-90-7
- Chemical Name:
- Acetyl tributyl citrate
- Synonyms
- ATBC;TRIBUTYL ACETYLCITRATE;Acetyltributylcitrat;TRIBUTYL O-ACETYLCITRATE;Tributyl citrate acetate;citroflexa4;Acetyl butyl citrate;tributylcitrateacetate;ACETYL TRI-N-BUTYL CITRATE;tributyl 2-acetoxypropane-1,2,3-tricarboxylate
- CBNumber:
- CB0408022
- Molecular Formula:
- C20H34O8
- Molecular Weight:
- 402.48
- MDL Number:
- MFCD00043554
- MOL File:
- 77-90-7.mol
- MSDS File:
- SDS
| Melting point | -59 °C |
|---|---|
| Boiling point | 327 °C |
| Density | 1.05 g/mL at 25 °C (lit.) |
| Pour Point | -43 |
| vapor pressure | 0.26 psi ( 20 °C) |
| refractive index |
n |
| FEMA | 3080 | TRIBUTYL ACETYLCITRATE |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride. |
| form | Liquid |
| color | Clear Colourless |
| Odor | at 100.00 %. very faint herbal wine sweet |
| Odor Type | herbal |
| Viscosity | 32.7cp (25C) |
| Water Solubility | <0.1 g/100 mL |
| FreezingPoint | -80℃ |
| JECFA Number | 630 |
| BRN | 2303316 |
| InChIKey | QZCLKYGREBVARF-UHFFFAOYSA-N |
| LogP | 5.227 (est) |
| CAS DataBase Reference | 77-90-7(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | TRIBUTYL ACETYLCITRATE |
| FDA 21 CFR | 172.515; 175.105; 175.300; 175.320; 181.27 |
| EWG's Food Scores | 1 |
| FDA UNII | 0ZBX0N59RZ |
| NIST Chemistry Reference | 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7) |
| EPA Substance Registry System | Acetyl tributyl citrate (77-90-7) |
| Cosmetics Info | Acetyl Tributyl Citrate |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WGK Germany | 3 | |||||||||
| RTECS | TZ8330000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29181500 | |||||||||
| NFPA 704 |
|
Acetyl tributyl citrate price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1009901 | Acetyltributyl citrate United States Pharmacopeia (USP) Reference Standard | 77-90-7 | 500mg | $450 | 2022-05-15 | Buy |
| TCI Chemical | A0822 | Tributyl O-Acetylcitrate >97.0%(GC) | 77-90-7 | 25mL | $17 | 2024-03-01 | Buy |
| TCI Chemical | A0822 | Tributyl O-Acetylcitrate >97.0%(GC) | 77-90-7 | 500mL | $54 | 2024-03-01 | Buy |
| scipoly | P-107 | Acetyl tri-n-butyl citrate | 77-90-7 | 100g | $14 | 2024-07-03 | Buy |
| scipoly | P-107 | Acetyl tri-n-butyl citrate | 77-90-7 | 250g | $28 | 2024-07-03 | Buy |
Acetyl tributyl citrate Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid
Chemical Properties
Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.
Chemical Properties
Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.
Chemical Properties
Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.
Uses
plasticizer flavoring agent
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses
Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.
Definition
Aqueous-based pharmaceutical coat- ings.
Production Methods
Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.
Preparation
From citric acid via the tributyl ester followed by acetylation.
Taste threshold values
An emulsion of the title material in water at 1000 ppm has only a very faint, mildly fruity-winey, berry-like odor and a mild, nondescript taste.
General Description
Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes. ADD750
Safety
and films intended for direct food contact. It is also used in selfadhesive
thin films used for topical delivery systems. It is generally
regarded as a relatively nontoxic and nonirritating material.
However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg
Carcinogenicity
The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.
Solubility in organics
Miscible with alcohol and oils.
storage
Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.
Incompatibilities
Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.
Regulatory Status
Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.
Acetyl tributyl citrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changyi Longchang Bio-Chemical Co., LTD | +8613256193735 | info@longchangchemical.com | China | 990 | 58 |
| Anhui Royal Chemical Co., Ltd. | +86-25-86655873 +8613962173137 | marketing@royal-chem.com | China | 193 | 55 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 662 | 58 |
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View Lastest Price from Acetyl tributyl citrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | Acetyl tributyl citrate
77-90-7
|
US $100.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-22 | butyl acetylcitrate
77-90-7
|
US $60.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-22 | ACETYL TRIBUTYL CITRATE
77-90-7
|
US $770.00 / kg | 1000kg | 99% | 20 tons | Anhui Royal Chemical Co., Ltd. |
-
- Acetyl tributyl citrate
77-90-7
- US $100.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- butyl acetylcitrate
77-90-7
- US $60.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- ACETYL TRIBUTYL CITRATE
77-90-7
- US $770.00 / kg
- 99%
- Anhui Royal Chemical Co., Ltd.