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4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole structure

CAS No.: 931314-31-7

Chemical Name:: 4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole

Synonyms: Specific PXR antagonist 70;SPA70-LC-1|SpecificPXRantagonist70;SPA70,Inhibitor,cancer,hPXR,SPA 70,inhibit,pregnane X receptor,SPA-70;4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole;1H-1,2,3-Triazole, 1-(2,5-dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl-

CBNumber:: CB04195506

Molecular Formula:: C21H25N3O4S

Molecular Weight:: 415.51

MDL Number:: MFCD14774311

MOL File:: 931314-31-7.mol

Last updated:2024-07-02 08:54:58

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4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole Properties

Boiling point	612.6±65.0 °C(Predicted)
Density	1.22±0.1 g/cm3(Predicted)
solubility	Chloroform: 10 mg/ml
form	A solid
pka	-7.17±0.70(Predicted)
color	Off-white to pink

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	HTS004238	4-[(4-tert-butylphenyl)sulfonyl]-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole	931314-31-7	1mg	$39	2021-12-16	Buy

Product number	Packaging	Price	Buy
HTS004238	1mg	$39	Buy

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole Chemical Properties,Uses,Production

Biological Activity

SPA70 is a pregnane X receptor (PXR) antagonist (IC50 = 0.51 μM).1 It is selective for PXR over 10 additional nuclear receptors at concentrations greater than 5 μM, as well as over a panel of 384 kinases at 10 μM. SPA70 (0.1-10 μM) inhibits PXR activation induced by rifampicin in HEK293 cells expressing the human receptor. It also inhibits rifampicin-induced activity of the PXR target cytochrome P450 (CYP) isoform 3A4 (CYP3A4) in primary human hepatocytes. SPA70 (200 mg/kg) inhibits PXR agonist-induced CYP3A4-mediated metabolism of midazolam and paclitaxel in human PXR transgenic (hPXR-tg) mice.

References

1.Lin, W., Wang, Y.-M., Chai, S.C., et al.SPA70 is a potent antagonist of human pregnane X receptorNat. Commun.8(1)741(2017)

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23960	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4659	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28068	58

Supplier	Advantage
Shanghai EFE Biological Technology Co., Ltd.	58
Changzhou Furuisi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole Spectrum

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole(931314-31-7)¹HNMR

4-(4-tert-butylbenzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole SPA70,Inhibitor,cancer,hPXR,SPA 70,inhibit,pregnane X receptor,SPA-70 1H-1,2,3-Triazole, 1-(2,5-dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl- SPA70-LC-1|SpecificPXRantagonist70 Specific PXR antagonist 70 931314-31-7